RGD Reference Report - Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. - Rat Genome Database

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Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases.

Authors: Kawahito, Y  Cannon, GW  Gulko, PS  Remmers, EF  Longman, RE  Reese, VR  Wang, J  Griffiths, MM  Wilder, RL 
Citation: Kawahito Y, etal., J Immunol 1998 Oct 15;161(8):4411-9
RGD ID: 61035
Pubmed: PMID:9780220   (View Abstract at PubMed)

Adjuvant-induced arthritis (AIA) in rats is a widely used autoimmune experimental model with many features similar to rheumatoid arthritis (RA). To identify potential genetic regulatory mechanisms in RA, we conducted genome-wide linkage analysis in F2 progeny of arthritis-susceptible Dark Agouti (DA) and relatively resistant Fischer 344 (F344) inbred rats. We compared the data with our previously reported investigation of collagen-induced arthritis (CIA), which was expanded in the follow-up study reported in this work. We found two quantitative trait loci (QTLs) in common, i.e., Aia1/Cia1 on chromosome 20, which includes the MHC, and Aia3/Cia3 on chromosome 4. We also identified a second unique QTL in AIA, Aia2, on chromosome 4. Interestingly, the QTL region on chromosome 4 (Aia3/Cia3), like the MHC, appears to be involved in several other autoimmune diseases in rats, including insulin-dependent diabetes, thyroiditis, and experimental autoimmune uveitis. Moreover, an analysis of conserved synteny among rats, mice, and humans suggested that Aia2 and Aia3/Cia3, like Aia1/Cia1, contain candidate genes for several autoimmune/inflammatory diseases in mice and humans, including diabetes, systemic lupus erythematosus, inflammatory bowel disease, asthma/atopy, multiple sclerosis, and RA. The rat models appear to provide a powerful complementary approach to identify and characterize candidate genes that may contribute to autoimmune diseases in several species.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Aia1RatExperimental Arthritis  IDA  RGD 
Aia2RatExperimental Arthritis  IDA  RGD 
Aia3RatExperimental Arthritis  IDA  RGD 
Aia4RatExperimental Arthritis  IDA  RGD 
Bp79Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Aia2Ratjoint inflammation  QTM  RGD 
Aia1Ratjoint swelling  QTM  RGD 
Aia2Ratjoint swelling  QTM  RGD 
Aia3Ratjoint swelling  QTM  RGD 
Aia4Ratjoint swelling  QTM  RGD 
Objects Annotated

QTLs
Aia1  (Adjuvant induced arthritis QTL 1)
Aia2  (Adjuvant induced arthritis QTL 2)
Aia3  (Adjuvant induced arthritis QTL 3)
Aia4  (Adjuvant induced arthritis QTL 4)
Bp79  (Blood pressure QTL 79)

Strains
DA  (DA)
F344/NRrrc  (NA)

Objects referenced in this article
Marker D4Arb16 D4Arb16 Rattus norvegicus
Marker D20Arb2 D20Arb2 Rattus norvegicus
Marker D20Wox3 D20Wox3 Rattus norvegicus
Marker D15Mit6 D15Mit6 Rattus norvegicus
Marker D4Mgh15 D4Mgh15 Rattus norvegicus
Marker D15Mgh3 D15Mgh3 Rattus norvegicus
Marker D15Rat22 D15Rat22 Rattus norvegicus
Marker D4Arb26 D4Arb26 Rattus norvegicus
Marker D4Arb30 D4Arb30 Rattus norvegicus
Marker D4Arb24 D4Arb24 Rattus norvegicus
Marker D20Arb8 D20Arb8 Rattus norvegicus
QTL Cia1 Collagen induced arthritis QTL 1 Rattus norvegicus
QTL Ciaa1 CIA Autoantibody QTL 1 Rattus norvegicus
QTL Eau1 Experimental allergic uveoretinitis QTL 1 Rattus norvegicus
QTL Iddm4 Insulin dependent diabetes mellitus QTL 4 Rattus norvegicus
Gene Npy neuropeptide Y Rattus norvegicus
QTL Pia1 Pristane induced arthritis QTL 1 Rattus norvegicus
QTL Pia2 Pristane induced arthritis QTL 2 Rattus norvegicus
Gene Tcrb T-cell receptor beta chain Rattus norvegicus

Additional Information