RGD Reference Report - Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis.

Authors: Bergsteinsdottir, K  Yang, HT  Pettersson, U  Holmdahl, R 
Citation: Bergsteinsdottir K, etal., J Immunol 2000 Feb 1;164(3):1564-8
RGD ID: 61031
Web Url: http://www.jimmunol.org/cgi/content/abstract/164/3/1564
Pubmed: PMID:10640775   (View Abstract at PubMed)

The pathogenicity of multiple sclerosis is still poorly understood, but identification of susceptibility genes using the animal model experimental allergic encephalomyelitis (EAE) could provide leads. Certain genes may be shared between different autoimmune diseases, and identification of such genes is of obvious importance. To locate gene regions involved in the control of EAE and to compare the findings with the susceptibility loci recently identified in a model for rheumatoid arthritis (pristane-induced arthritis), we made crosses between the encephalomyelitis- and arthritis-susceptible rat strain DA and the resistant E3 strain. Genetic analysis of animals produced in a F2 intercross identified 11 loci associated with specific EAE-associated traits. Interestingly, five of these loci were situated at the same position as major loci controlling pristane-induced arthritis and showed similarities in inheritance pattern and subphenotype associations. Our results show that different phases of EAE are controlled by different sets of genes and that common genes are likely to be involved in different autoimmune diseases.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype

Objects Annotated

QTLs
Eae1  (Experimental allergic encephalomyelitis QTL 1)
Eae10  (Experimental allergic encephalomyelitis QTL 10)
Eae11  (Experimental allergic encephalomyelitis QTL 11)
Eae5  (Experimental allergic encephalomyelitis QTL 5)
Eae6  (Experimental allergic encephalomyelitis QTL 6)
Eae7  (Experimental allergic encephalomyelitis QTL 7)
Eae8  (Experimental allergic encephalomyelitis QTL 8)
Eae9  (Experimental allergic encephalomyelitis QTL 9)
Eaex  (Experimental allergic encephalomyelitis QTL x)
Eaey  (Experimental allergic encephalomyelitis QTL y)
Eaez  (Experimental allergic encephalomyelitis QTL z)

Strains
DA  (DA)
DA/Ztm  (NA)
E3  (NA)
E3/Ztm  (NA)

Objects referenced in this article
Marker D14Wox11 D14Wox11 Rattus norvegicus
Marker D18Wox13 D18Wox13 Rattus norvegicus
Marker D1Mgh12 D1Mgh12 Rattus norvegicus
Marker D1Mit13 D1Mit13 Rattus norvegicus
Marker D12Mit2 D12Mit2 Rattus norvegicus
Marker D4Wox30 D4Wox30 Rattus norvegicus
Marker D19Mit9 D19Mit9 Rattus norvegicus
Marker D14Mit6 D14Mit6 Rattus norvegicus
Marker D5Mit10 D5Mit10 Rattus norvegicus
Marker D1Mit7 D1Mit7 Rattus norvegicus
Marker D19Mit5 D19Mit5 Rattus norvegicus
Marker D6Mgh3 D6Mgh3 Rattus norvegicus
Marker D18Mgh1 D18Mgh1 Rattus norvegicus
Marker D20Mgh4 D20Mgh4 Rattus norvegicus
Marker D1Mgh9 D1Mgh9 Rattus norvegicus
Marker D4Mgh14 D4Mgh14 Rattus norvegicus
Marker D12Rat9 D12Rat9 Rattus norvegicus
Marker D6Rat10 D6Rat10 Rattus norvegicus
Marker D20Rat41 D20Rat41 Rattus norvegicus
Marker D5Wox21 D5Wox21 Rattus norvegicus
QTL Pia1 Pristane induced arthritis QTL 1 Rattus norvegicus
QTL Pia2 Pristane induced arthritis QTL 2 Rattus norvegicus
QTL Pia21 Pristane induced arthritis QTL 21 Rattus norvegicus
QTL Pia6 Pristane induced arthritis QTL 6 Rattus norvegicus

Additional Information