RGD Reference Report - Impaired autoregulation of renal blood flow in the fawn-hooded rat. - Rat Genome Database

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Impaired autoregulation of renal blood flow in the fawn-hooded rat.

Authors: Van Dokkum, RP  Alonso-Galicia, M  Provoost, AP  Jacob, HJ  Roman, RJ 
Citation: Van Dokkum RP, etal., Am J Physiol 1999 Jan;276(1 Pt 2):R189-96
RGD ID: 61028
Pubmed: PMID:9887194   (View Abstract at PubMed)

The responses to changes in renal perfusion pressure (RPP) were compared in 12-wk-old fawn-hooded hypertensive (FHH), fawn-hooded low blood pressure (FHL), and August Copenhagen Irish (ACI) rats to determine whether autoregulation of renal blood flow (RBF) is altered in the FHH rat. Mean arterial pressure was significantly higher in conscious, chronically instrumented FHH rats than in FHL rats (121 +/- 4 vs. 109 +/- 6 mmHg). Baseline arterial pressures measured in ketamine-Inactin-anesthetized rats averaged 147 +/- 2 mmHg (n = 9) in FHH, 132 +/- 2 mmHg (n = 10) in FHL, and 123 +/- 4 mmHg (n = 9) in ACI rats. Baseline RBF was significantly higher in FHH than in FHL and ACI rats and averaged 9.6 +/- 0.7, 7.4 +/- 0.5, and 7.8 +/- 0.9 ml. min-1. g kidney wt-1, respectively. RBF was autoregulated in ACI and FHL but not in FHH rats. Autoregulatory indexes in the range of RPPs from 100 to 150 mmHg averaged 0.96 +/- 0.12 in FHH vs. 0.42 +/- 0.04 in FHL and 0.30 +/- 0.02 in ACI rats. Glomerular filtration rate was 20-30% higher in FHH than in FHL and ACI rats. Elevations in RPP from 100 to 150 mmHg increased urinary protein excretion in FHH rats from 27 +/- 2 to 87 +/- 3 &mgr;g/min, whereas it was not significantly altered in FHL or ACI rats. The percentage of glomeruli exhibiting histological evidence of injury was not significantly different in the three strains of rats. These results indicate that autoregulation of RBF is impaired in FHH rats before the development of glomerulosclerosis and suggest that an abnormality in the control of renal vascular resistance may contribute to the development of proteinuria and renal failure in this strain of rats.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FHL/EurMcwiRatdecreased renal glomerular filtration rate  IAGP compared to FHH/EurMcw and ACI/SegHsdRGD 
FHH/EurMcwiRatincreased mean systemic arterial blood pressure  IAGP compared to FHL/EurMcwiRGD 
FHH/EurMcwiRatincreased urine protein level  IAGP compared to FHL/EurMcw and ACI/SegHsdRGD 
FHL/EurMcwiRatincreased urine protein level  IAGP compared to ACI/SegHsdRGD 
Objects Annotated

Strains
FHH/EurMcwi  (NA)
FHL/EurMcwi  (Fawn Hooded Low blood pressure)

Objects referenced in this article
Strain FHH Fawn Hooded Hypertensive Rattus norvegicus

Additional Information