RGD Reference Report - Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat. - Rat Genome Database

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Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat.

Authors: Van Dokkum, RP  Sun, CW  Provoost, AP  Jacob, HJ  Roman, RJ 
Citation: van Dokkum RP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R855-63
RGD ID: 61023
Web Url: http://ajpregu.physiology.org/cgi/content/full/276/3/R855
Pubmed: (View Article at PubMed) PMID:10070148

The present study examined whether an abnormality in the myogenic response of renal arterioles that impairs autoregulation of renal blood flow (RBF) and glomerular capillary pressure (PGC) contributes to the development of renal damage in fawn-hooded hypertensive (FHH) rats. Autoregulation of whole kidney, cortical, and medullary blood flow and PGC were compared in young (12 wk old) FHH and fawn-hooded low blood pressure (FHL) rats in volume-replete and volume-expanded conditions. Baseline RBF, cortical and medullary blood flow, and PGC were significantly greater in FHH than in FHL rats. Autoregulation of renal and cortical blood flow was significantly impaired in FHH rats compared with results obtained in FHL rats. Myogenically mediated autoregulation of PGC was significantly greater in FHL than in FHH rats. PGC rose from 46 +/- 1 to 71 +/- 2 mmHg in response to an increase in renal perfusion pressure from 100 to 150 mmHg in FHH rats, whereas it only increased from 39 +/- 2 to 53 +/- 1 mmHg in FHL rats. Isolated perfused renal interlobular arteries from FHL rats constricted by 10% in response to elevations in transmural pressure from 70 to 120 mmHg. In contrast, the diameter of vessels from FHH rats increased by 15%. These results indicate that the myogenic response of small renal arteries is altered in FHH rats, and this contributes to an impaired autoregulation of renal blood flow and elevations in PGC in this strain.


Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

FHH/EurMcwi  (NA)

Objects referenced in this article
Strain ACI/N A X C 9935, Irish Rattus norvegicus
Strain FHH/Eur null Rattus norvegicus
Strain FHL null Rattus norvegicus
Strain FHL/Eur Fawn Hooded Low blood pressure Rattus norvegicus

Additional Information