RGD Reference Report - Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.

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General

Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.
Authors:	Wei, S Wei, K Moralejo, DH Ogino, T Koike, G Jacob, HJ Sugiura, K Sasaki, Y Yamada, T Matsumoto, K
Citation:	Wei S, etal., Mamm Genome 1999 Mar;10(3):249-58
RGD ID:	61021
Web Url:	http://link.springer-ny.com/link/service/journals/00335/bibs/10n3p249.html
Pubmed:	PMID:10051320 (View Abstract at PubMed)
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, non-insulin-dependent diabetes mellitus (NIDDM) in humans. We have previously reported four quantitative trait loci (QTLs) responsible for NIDDM on Chromosomes (Chrs) 7, 14, 8, and 11 (Nidd1-4/of for Non-insulin-dependent diabetes1-4/oletf) by a whole-genome search in 160 F2 progenies obtained by mating the OLETF and the Fischer-344 (F344) rats. Our present investigation was designed to identify and characterize novel QTLs affecting NIDDM by performing a genome-wide linkage analysis of genes for glucose levels and body weight and analysis for gene-to-gene and gene-to-body-weight interactions on an improved genetic map with a set of 382 informative markers in the 160 F2 progenies. We have identified seven novel QTLs on rat Chrs 1 (Nidd5 and 6/of), 5 (Nidd7/of), 9 (Nidd8/of), 12 (Nidd9/of), 14 (Nidd10/of) and 16 (Nidd11/of) which, together with the Nidd1-4/of, account for a total of approximately 60% and approximately 75% of the genetic variance of the fasting and postprandial glucose levels, respectively, in the F2. While the OLETF allele corresponds with increased glucose levels as expected for the novel QTLs except Nidd8 and 9/of, the Nidd8 and 9/of exhibit heterosis: heterozygotes showing significantly higher glucose levels than OLETF or F344 homozygotes. There are epistatic interactions between Nidd1 and 10/of and between Nidd2 and 8/of. Additionally, our results indicated that the Nidd6 and 11/of could also contribute to an increase of body weight, and that the other five QTLs could show no linkage with body weight, but Nidd8,9, and 10/of have an interaction with body weight.

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Disease Annotations

type 2 diabetes mellitus (IDA)

Phenotype Annotations

Mammalian Phenotype

impaired glucose tolerance (QTM)

Objects Annotated

QTLs

Bw120 (Body weight QTL 120)

Niddm21 (Non-insulin dependent diabetes mellitus QTL 21)

Niddm6 (Non-insulin dependent diabetes mellitus QTL 6)

Strains

F344/DuCrlCrlj (NA)

OLETF/Got (Otsuka Long Evans Tokushima)

Objects referenced in this article

Strain	OLETF	Otsuka Long-Evans Tokushima fatty	Rattus norvegicus

Additional Information

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Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.

Mammalian Phenotype