RGD Reference Report - Effects of resveratrol on rat neurosteroid synthetic enzymes. - Rat Genome Database

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Effects of resveratrol on rat neurosteroid synthetic enzymes.

Authors: Wang, Yiluan  Sun, Jianliang  Chen, Ling  Zhou, Songyi  Lin, Han  Wang, Yiyan  Lin, Nengming  Ge, Ren-Shan 
Citation: Wang Y, etal., Fitoterapia. 2017 Oct;122:61-66. doi: 10.1016/j.fitote.2017.08.005. Epub 2017 Aug 18.
RGD ID: 597621558
Pubmed: PMID:28823883   (View Abstract at PubMed)
DOI: DOI:10.1016/j.fitote.2017.08.005   (Journal Full-text)

Resveratrol, a common polyphenol, has extensive pharmacological activities. Resveratrol inhibits some steroid biosynthetic enzymes, indicating that it may block neurosteroid synthesis. The objective of the present study is to investigate the inhibition of resveratrol on neurosteroidogenic enzymes rat 5α-reductase 1 (SRD5A1), 3α-hydroxysteroid dehydrogenase (AKR1C9), and retinol dehydrogenase 2 (RDH2). The IC50 values of resveratrol on SRD5A1, AKR1C9, and RDH2 were >100μM, 0.436±0.070μM, and 4.889±0.062μM, respectively. Resveratrol competitively inhibited rat AKR1C9 and RDH2 against steroid substrates. Docking showed that resveratrol bound to the steroid binding pocket of AKR1C9. It exerted a mixed mode on these AKR1C9 and RDH2 against cofactors. In conclusion, resveratrol potently inhibited rat AKR1C9 and RDH2 to regulate local neurosteroid levels.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Akr1c14Ratresponse to resveratrol  IEP  RGD 
Rdh16Ratresponse to resveratrol  IEP  RGD 
Srd5a1Ratresponse to resveratrol  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Akr1c14  (aldo-keto reductase family 1, member C14)
Rdh16  (retinol dehydrogenase 16)
Srd5a1  (steroid 5 alpha-reductase 1)


Additional Information