RGD Reference Report - Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord. - Rat Genome Database

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Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord.

Authors: Fabes, J  Anderson, P  Brennan, C  Bolsover, S 
Citation: Fabes J, etal., Eur J Neurosci. 2007 Nov;26(9):2496-505. Epub 2007 Oct 26.
RGD ID: 5688750
Pubmed: PMID:17970742   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1460-9568.2007.05859.x   (Journal Full-text)

Spinal cord injury often leads to permanent incapacity because long axons cannot regenerate in the CNS. Eph receptors inhibit axon extension through an effect on the actin cytoskeleton. We have previously reported that after injury EphA4 appears at high levels in stumps of corticospinal axons, while a cognate ligand, ephrinB2, is upregulated at the lesion site so as to confine the injured axons. In this study we have infused lesioned spinal cords with a peptide antagonist of EphA4. In treated animals the retrograde degeneration that normally follows corticospinal tract injury is absent. Rather, corticospinal tract axons sprout up to and into the lesion centre. In a behavioural test of corticospinal tract function, peptide treatment substantially improved recovery relative to controls. These results suggest that blocking EphA4 is likely to contribute to a future successful clinical treatment for spinal cord injury.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EPHA4HumanSpinal Cord Injuries  ISOEpha4 (Rattus norvegicus) RGD 
Epha4MouseSpinal Cord Injuries  ISOEpha4 (Rattus norvegicus) RGD 
Epha4RatSpinal Cord Injuries  IMP  RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Epha4Ratnegative regulation of axon regeneration  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Epha4  (Eph receptor A4)

Genes (Mus musculus)
Epha4  (Eph receptor A4)

Genes (Homo sapiens)
EPHA4  (EPH receptor A4)


Additional Information