RGD Reference Report - Serum adiponectin and transient elastography as non-invasive markers for postoperative biliary atresia. - Rat Genome Database

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Serum adiponectin and transient elastography as non-invasive markers for postoperative biliary atresia.

Authors: Honsawek, S  Chayanupatkul, M  Chongsrisawat, V  Theamboonlers, A  Praianantathavorn, K  Udomsinprasert, W  Vejchapipat, P  Poovorawan, Y 
Citation: Honsawek S, etal., BMC Gastroenterol. 2011 Feb 28;11:16.
RGD ID: 5686894
Pubmed: PMID:21356120   (View Abstract at PubMed)
PMCID: PMC3053237   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-230X-11-16   (Journal Full-text)

BACKGROUND: Biliary atresia (BA) is a progressive inflammatory disorder of the extrahepatic bile ducts leading to the obliteration of bile flow. The purpose of this study was to determine serum adiponectin in BA patients and to investigate the relationship of adiponectin with clinical parameters and liver stiffness scores. METHODS: Sixty BA patients post Kasai operation and 20 controls were enrolled. The mean age of BA patients and controls was 9.6 +/- 0.7 and 10.1 +/- 0.7 years, respectively. BA patients were classified into two groups according to their serum total bilirubin (TB) levels (non-jaundice, TB < 2 mg/dl vs. jaundice, TB >/= 2 mg/dl) and liver stiffness (insignificant fibrosis, liver stiffness < 7 kPa vs. significant fibrosis, liver stiffness >/= 7 kPa). Serum adiponectin levels were analyzed by enzyme-linked immunosorbent assay. Liver stiffness scores were examined by transient elastography (FibroScan). RESULTS: BA patients had markedly higher serum adiponectin levels (15.5 +/- 1.1 vs. 11.1 +/- 1.1 mug/ml, P = 0.03) and liver stiffness than controls (30.1 +/- 3.0 vs. 5.1 +/- 0.5 kPa, P < 0.001). Serum adiponectin levels were significantly elevated in BA patients with jaundice compared with those without jaundice (24.4 +/- 1.4 vs. 11.0 +/- 0.7 mug/ml, P < 0.001). In addition, BA patients with significant liver fibrosis had remarkably greater serum adiponectin than insignificant fibrosis counterparts (17.7 +/- 1.2 vs. 9.4 +/- 1.1 mug/ml, P < 0.001). Subsequent analysis revealed that serum adiponectin was positively correlated with total bilirubin, hyaluronic acid, and liver stiffness (r = 0.58, r = 0.46, and r = 0.60, P < 0.001, respectively). CONCLUSIONS: Serum adiponectin and liver stiffness values were higher in BA patients compared with normal participants. The elevated serum adiponectin levels also positively correlated with the degree of hepatic dysfunction and liver fibrosis. Accordingly, serum adiponectin and transient elastography could serve as the useful non-invasive biomarkers for monitoring the severity and progression in postoperative BA.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADIPOQHumanbiliary atresia  IEP protein:increased expression:serumRGD 
AdipoqRatbiliary atresia  ISOADIPOQ (Homo sapiens)protein:increased expression:serumRGD 
AdipoqMousebiliary atresia  ISOADIPOQ (Homo sapiens)protein:increased expression:serumRGD 
ADIPOQHumanJaundice  IEP associated with Biliary Atresia and protein:increased expression:serumRGD 
AdipoqRatJaundice  ISOADIPOQ (Homo sapiens)associated with Biliary Atresia and protein:increased expression:serumRGD 
AdipoqMouseJaundice  ISOADIPOQ (Homo sapiens)associated with Biliary Atresia and protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)


Additional Information