RGD Reference Report - The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. - Rat Genome Database

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The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release.

Authors: Krapivinsky, G  Mochida, S  Krapivinsky, L  Cibulsky, SM  Clapham, DE 
Citation: Krapivinsky G, etal., Neuron. 2006 Nov 9;52(3):485-96.
RGD ID: 5684965
Pubmed: PMID:17088214   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuron.2006.09.033   (Journal Full-text)

A longstanding hypothesis is that ion channels are present in the membranes of synaptic vesicles and might affect neurotransmitter release. Here we demonstrate that TRPM7, a member of the transient receptor potential (TRP) ion channel family, resides in the membrane of synaptic vesicles of sympathetic neurons, forms molecular complexes with the synaptic vesicle proteins synapsin I and synaptotagmin I, and directly interacts with synaptic vesicular snapin. In sympathetic neurons, changes in TRPM7 levels and channel activity alter acetylcholine release, as measured by EPSP amplitudes and decay times in postsynaptic neurons. TRPM7 affects EPSP quantal size, an intrinsic property of synaptic vesicle release. Targeted peptide interference of TRPM7's interaction with snapin affects the amplitudes and kinetics of postsynaptic EPSPs. Thus, vesicular TRPM7 channel activity is critical to neurotransmitter release in sympathetic neurons.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Trpm7Ratsynaptic vesicle membrane  IDA  RGD 
Trpm7Ratvaricosity  IDA  RGD 

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Snapin  (SNAP-associated protein)
Syn1  (synapsin I)
Syt1  (synaptotagmin 1)
Trpm7  (transient receptor potential cation channel, subfamily M, member 7)


Additional Information