RGD Reference Report - Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression. - Rat Genome Database

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Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression.

Authors: Veillet, AL  Haag, JD  Remfert, JL  Meilahn, AL  Samuelson, DJ  Gould, MN 
Citation: Veillet AL, etal., Cancer Prev Res (Phila). 2011 Jan;4(1):97-106.
RGD ID: 5684388
Pubmed: PMID:21205740   (View Abstract at PubMed)
PMCID: PMC3447625   (View Article at PubMed Central)
DOI: DOI:10.1158/1940-6207.CAPR-10-0187   (Journal Full-text)

Genetic factors have been estimated to account for at least 30% of a woman's risk to develop breast cancer. We have developed a rat model using Wistar Furth (WF) and Wistar Kyoto (WKy) strains to genetically identify mammary cancer susceptibility loci. The WKy allele of the mammary carcinogenesis susceptibility locus Mcs5c, was previously shown to reduce carcinoma multiplicity after 7,12-dimethylbenz-[a]anthracene (DMBA) exposure. In this study, Mcs5c was fine-mapped using WF.WKy congenic lines. Mcs5c was located to a region of approximately 176 kb on rat chromosome 5. One of the Mcs5c congenic lines containing a narrow Mcs5c WKy interval displayed a 40% decrease in average carcinoma number compared with WF-homozygous congenic controls after mammary carcinogenesis induction using two different models. As genetically mapped, the Mcs5c locus is located in a gene desert and thus is devoid of genes and annotated RNAs; thus, a genetic element in Mcs5c was hypothesized to regulate the expression of genes outside the locus. Tenascin c (Tnc) was identified as a candidate gene due to its reduced expression in thymus and ovarian tissues of Mcs5c WKy-homozygous congenic females compared with WF-homozygous congenic controls. This allele-specific differential expression is environmentally controlled.



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Objects referenced in this article
Marker D5Uwm76 D5Uwm76 Rattus norvegicus
Marker D5Uwm77 D5Uwm77 Rattus norvegicus
Marker D5Uwm78 D5Uwm78 Rattus norvegicus
Marker D5Uwm79 D5Uwm79 Rattus norvegicus
Marker D5Uwm80 D5Uwm80 Rattus norvegicus
Marker D5Uwm81 D5Uwm81 Rattus norvegicus
Marker D5Uwm82 D5Uwm82 Rattus norvegicus
Marker D5Uwm83 D5Uwm83 Rattus norvegicus
Marker D5Uwm84 D5Uwm84 Rattus norvegicus
Marker D5Uwm85 D5Uwm85 Rattus norvegicus
Marker D5Uwm86 D5Uwm86 Rattus norvegicus
Marker D5Uwm87 D5Uwm87 Rattus norvegicus
Marker D5Uwm88 D5Uwm88 Rattus norvegicus
Marker D5Uwm89 D5Uwm89 Rattus norvegicus
Marker D5Uwm90 D5Uwm90 Rattus norvegicus
Marker D5Uwm91 D5Uwm91 Rattus norvegicus
Marker D5Uwm92 D5Uwm92 Rattus norvegicus
Marker D5Uwm93 D5Uwm93 Rattus norvegicus
Marker D5Uwm94 D5Uwm94 Rattus norvegicus
Marker D5Uwm95 D5Uwm95 Rattus norvegicus
Marker D5Uwm96 D5Uwm96 Rattus norvegicus
Marker D5Uwm97 D5Uwm97 Rattus norvegicus
Marker D5Uwm98 D5Uwm98 Rattus norvegicus
QTL Mcs14 Mammary carcinoma susceptibility QTL 14 Rattus norvegicus
Strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm null Rattus norvegicus

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