RGD Reference Report - HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients. - Rat Genome Database

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HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients.

Authors: Caliz, R  Atsumi, T  Kondeatis, E  Amengual, O  Khamashta, MA  Vaughan, RW  Lanchbury, JS  Hughes, GR 
Citation: Caliz R, etal., Rheumatology (Oxford). 2001 Jan;40(1):31-6.
RGD ID: 5147862
Pubmed: PMID:11157139   (View Abstract at PubMed)

OBJECTIVES: We investigated the association between HLA class II haplotypes and antiphospholipid syndrome (APS). METHODS: HLA DRB1, DQB1 and DQA1 genotypes were determined by the polymerase chain reaction using sequence-specific primers in 83 Caucasoid British patients with APS. The genotype frequencies were compared between subgroups of patients and 177 healthy controls. RESULTS: DQB1*0604/5/6/7/9-DQA1*0102-DRB1*1302 and DQB1*0303-DQA1*0201-DRB1*0701 haplotypes showed significantly positive correlations with APS [P=0.0087 and P=0.0012, respectively]. The association of the former was enhanced in primary APS patients with anti-beta 2-glycoprotein I antibodies (anti-beta 2GPI) [odds ratio 6.2, 95% confidence interval (2.2-17.6), P=0.0014, corrected P=0.042]. CONCLUSIONS: These alleles and haplotypes might affect anti-ss2GPI production and APS development in different and heterogeneous fashion.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
antiphospholipid syndrome  ISOHLA-DQA1 (Homo sapiens)5147862; 5147862DNA:polymorphism (human)RGD 
antiphospholipid syndrome  ISOHLA-DQB1 (Homo sapiens)5147862; 5147862DNA:polymorphisms: :multiple (human)RGD 
antiphospholipid syndrome  ISOHLA-DRB1 (Homo sapiens)5147862; 5147862DNA:polymorphism (human)RGD 
antiphospholipid syndrome  IAGP 5147862; 5147862DNA:polymorphisms (human)RGD 
antiphospholipid syndrome  IAGP 5147862DNA:polymorphisms: :multiple (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)
RT1-Bb  (RT1 class II, locus Bb)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information