RGD Reference Report - Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. - Rat Genome Database

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Titanium dioxide nanoparticles induce emphysema-like lung injury in mice.

Authors: Chen, HW  Su, SF  Chien, CT  Lin, WH  Yu, SL  Chou, CC  Chen, JJ  Yang, PC 
Citation: Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
RGD ID: 5135245
Pubmed: PMID:17023518   (View Abstract at PubMed)
DOI: DOI:10.1096/fj.06-6485fje   (Journal Full-text)

Titanium dioxide nanoparticles (nanoTiO2) have been widely used as a photocatalyst in air and water cleaning. However, these nanoparticles inhalation can induce pulmonary toxicity and its mechanism is not fully understood. In this study we investigated the pulmonary toxicity of nanoTiO2 and its molecular pathogenesis. The adult male ICR mice were exposed to intratracheal single dose of 0.1 or 0.5 mg nanoTiO2 (19-21 nm) and lung tissues were collected at 3rd day, 1st wk, and 2nd wk for morphometric, microarray gene expression, and pathway analyses. NanoTiO2 can induce pulmonary emphysema, macrophages accumulation, extensive disruption of alveolar septa, type II pneumocyte hyperplasia, and epithelial cell apoptosis. NanoTiO2 induced differential expression of hundreds of genes include activation of pathways involved in cell cycle, apoptosis, chemokines, and complement cascades. In particular, nanoTiO2 up-regulates placenta growth factor (PlGF) and other chemokines (CXCL1, CXCL5, and CCL3) expressions that may cause pulmonary emphysema and alveolar epithelial cell apoptosis. Cultured human THP-1 cell-derived macrophages treated with nanoTiO2 in vitro also resulted in up-regulations of PlGF, CXCL1, CXCL5, and CCL3. These results indicated that nanoTiO2 can induce severe pulmonary emphysema, which may be caused by activation of PlGF and related inflammatory pathways.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CXCL1Humanpulmonary emphysema  ISOCxcl1 (Mus musculus)mRNA:increased expression:lungRGD 
CXCL3Humanpulmonary emphysema  ISOCxcl3 (Mus musculus)mRNA:increased expression:lungRGD 
CXCL5Humanpulmonary emphysema  ISOCxcl5 (Mus musculus)mRNA:increased expression:lungRGD 
Cxcl1Ratpulmonary emphysema  ISOCxcl1 (Mus musculus)mRNA:increased expression:lungRGD 
Cxcl1Mousepulmonary emphysema  IEP mRNA:increased expression:lungRGD 
Cxcl3Ratpulmonary emphysema  ISOCxcl3 (Mus musculus)mRNA:increased expression:lungRGD 
Cxcl3Mousepulmonary emphysema  IEP mRNA:increased expression:lungRGD 
Cxcl5Mousepulmonary emphysema  IEP mRNA:increased expression:lungRGD 
Cxcl6Ratpulmonary emphysema  ISOCxcl5 (Mus musculus)mRNA:increased expression:lungRGD 
PGFHumanpulmonary emphysema  ISOPgf (Mus musculus)mRNA, protein:increased expression:lung, plasmaRGD 
PgfRatpulmonary emphysema  ISOPgf (Mus musculus)mRNA, protein:increased expression:lung, plasmaRGD 
PgfMousepulmonary emphysema  IEP mRNA, protein:increased expression:lung, plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl1  (C-X-C motif chemokine ligand 1)
Cxcl3  (C-X-C motif chemokine ligand 3)
Cxcl6  (C-X-C motif chemokine ligand 6)
Pgf  (placental growth factor)

Genes (Mus musculus)
Cxcl1  (C-X-C motif chemokine ligand 1)
Cxcl3  (C-X-C motif chemokine ligand 3)
Cxcl5  (C-X-C motif chemokine ligand 5)
Pgf  (placental growth factor)

Genes (Homo sapiens)
CXCL1  (C-X-C motif chemokine ligand 1)
CXCL3  (C-X-C motif chemokine ligand 3)
CXCL5  (C-X-C motif chemokine ligand 5)
PGF  (placental growth factor)


Additional Information