RGD Reference Report - Elevated levels of interferon gamma-inducible protein-10 and epithelial neutrophil-activating peptide-78 in patients with pulmonary sarcoidosis. - Rat Genome Database

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Elevated levels of interferon gamma-inducible protein-10 and epithelial neutrophil-activating peptide-78 in patients with pulmonary sarcoidosis.

Authors: Sugiyama, K  Mukae, H  Ishii, H  Kakugawa, T  Ishimoto, H  Nakayama, S  Shirai, R  Fujii, T  Mizuta, Y  Kohno, S 
Citation: Sugiyama K, etal., Respirology. 2006 Nov;11(6):708-14.
RGD ID: 5135244
Pubmed: PMID:17052298   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1440-1843.2006.00933.x   (Journal Full-text)

OBJECTIVE AND BACKGROUND: Interferon gamma-inducible protein (IP)-10 and epithelial neutrophil-activating peptide (ENA)-78 belong to the CXC chemokine family and are important factors in inflammatory lung diseases. In sarcoidosis, the potential role of IP-10 to regulate the migration and activation of T-cells towards sites of sarcoid activity has been suggested. METHODS: In this study, the concentrations of IP-10 and ENA-78 in the serum and BAL fluid of patients with different stages of active pulmonary sarcoidosis (n=41) and healthy subjects (n=12) were measured by enzyme-linked immunosorbent assay to evaluate the contribution of these CXC chemokines to this disease. RESULTS: Serum and BAL fluid concentrations of IP-10 and BAL fluid levels of ENA-78 in patients with sarcoidosis were significantly higher than those in control subjects. The serum levels of IP-10 were significantly increased only in patients with stages I and II sarcoidosis, while BAL fluid levels of ENA-78 were increased only in stage III sarcoidosis. In addition, serum concentrations of IP-10 were elevated in patients with extrapulmonary lesions compared with those without such lesions. In patients with sarcoidosis, IP-10 concentrations in BAL fluid correlated with lymphocyte proportions in BAL fluid. CONCLUSION: IP-10 may play an important role in regulating lymphocytes into the lung and that ENA-78 may be associated with lung parenchymal disease in pulmonary sarcoidosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CXCL5Humanpulmonary sarcoidosis disease_progressionIEP protein:increased expression:respiratory system fluid/secretion RGD 
Cxcl5Mousepulmonary sarcoidosis disease_progressionISOCXCL6 (Homo sapiens)protein:increased expression:respiratory system fluid/secretionRGD 
Cxcl6Ratpulmonary sarcoidosis disease_progressionISOCXCL6 (Homo sapiens)protein:increased expression:respiratory system fluid/secretionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl6  (C-X-C motif chemokine ligand 6)

Genes (Mus musculus)
Cxcl5  (C-X-C motif chemokine ligand 5)

Genes (Homo sapiens)
CXCL5  (C-X-C motif chemokine ligand 5)


Additional Information