RGD Reference Report - The effects of fluorouracil on thymidylate synthase and thymidine kinase in regenerating rat liver after partial hepatectomy. - Rat Genome Database

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The effects of fluorouracil on thymidylate synthase and thymidine kinase in regenerating rat liver after partial hepatectomy.

Authors: Tsukamoto, I  Kojo, S 
Citation: Tsukamoto I and Kojo S, Biochim Biophys Acta. 1991 May 24;1074(1):52-5.
RGD ID: 5133426
Pubmed: PMID:2043679   (View Abstract at PubMed)

The injection of 5-fluorouracil to partial hepatectomized rat prevented the rise of activities of thymidylate synthase and thymidine kinase as well as DNA synthesis in 24-h regenerating liver in a dose-dependent manner. The extent of the decrease of thymidine kinase activity was more than that of thymidylate synthase level. The immunoblotting assay showed the existence of fluorodeoxyuridine monophosphate bound thymidylate synthase in 5-fluorouracil injected rat liver. These results indicate that the reduction of DNA synthesis in regenerating liver by 5-fluorouracil result from the inhibitions of the rise of activities of both thymidylate synthase and thymidine kinase, while the mechanisms in their inhibitions may be different.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TymsRaturacil metabolic process  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tyms  (thymidylate synthetase)


Additional Information