RGD Reference Report - Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform. - Rat Genome Database

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Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform.

Authors: Tagashira, H  Hamazaki, K  Tanaka, N  Gao, C  Namba, M 
Citation: Tagashira H, etal., Int J Mol Med. 1998 Jul;2(1):65-8.
RGD ID: 5132885
Pubmed: PMID:9854145   (View Abstract at PubMed)

Increased expression of nm23/nucleoside diphosphate kinase (NDP kinase) has been reported to be associated with both reduced metastatic potential in breast carcinoma and tumor progression in colon adenocarcinoma and lung adenocarcinoma. We examined effects of expression of nm23-R2 rat NDP kinase alpha isoform on mouse adenocarcinoma cells (Colon 26 line) and found a significant reduction of metastatic potential along with overexpression of c-myc. We also found that the proliferation rate of the transformed cells was the same as that of the control cells in culture. These results indicate that the cell growth potential in vitro is irrelevant to metastatic potential of the cells in vivo.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nme2Ratdecreased metastatic potential  IMP  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Nme2  (NME/NM23 nucleoside diphosphate kinase 2)


Additional Information