RGD Reference Report - Excitatory responses of cardiovascular activities to urocortin3 administration into the PVN of the rat. - Rat Genome Database

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Excitatory responses of cardiovascular activities to urocortin3 administration into the PVN of the rat.

Authors: Li, X  Fan, M  Shen, L  Cao, Y  Zhu, D  Hong, Z 
Citation: Li X, etal., Auton Neurosci. 2010 Apr 19;154(1-2):108-11. Epub 2010 Jan 8.
RGD ID: 5130949
Pubmed: PMID:20060787   (View Abstract at PubMed)
DOI: DOI:10.1016/j.autneu.2009.12.004   (Journal Full-text)

Urocortin3 (Ucn3) is an endogenous ligand for corticotropin-releasing factor receptor subtype 2 (CRF2R). In this study, we examined its potential cardiovascular effects by microinjection of Ucn3 and anti-sauvagine 30 (ASV30), a selective antagonist of CRF2R, into the paraventricular nucleus (PVN) of the hypothalamus. After Ucn3 (10 pmol/100 nl) was microinjected into the PVN of anesthetized rats, significant increases of systolic blood pressure, heart rate and renal sympathetic nerve activity were observed. Furthermore, all these cardiovascular and autonomic effects induced by Ucn3 could be blocked totally by administration of ASV30 into the PVN. These results are consistent with the idea that Ucn3 might be involved in the central nervous control of cardiovascular function by acting centrally to increase sympathetic outflow via the activation of CRF2R within the PVN.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Crhr2Ratpositive regulation of blood pressure  IMP  RGD 
Crhr2Ratpositive regulation of heart rate  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crhr2  (corticotropin releasing hormone receptor 2)


Additional Information