RGD Reference Report - Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells. - Rat Genome Database

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Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells.

Authors: Karlsson, EA  Sheridan, PA  Beck, MA 
Citation: Karlsson EA, etal., J Nutr. 2010 Sep;140(9):1691-7. Epub 2010 Jun 30.
RGD ID: 5129154
Pubmed: PMID:20592105   (View Abstract at PubMed)
PMCID: PMC2924599   (View Article at PubMed Central)
DOI: DOI:10.3945/jn.110.123653   (Journal Full-text)

Obesity has been associated with increasing the risk for type 2 diabetes and heart disease, but its influence on the immune response to viral infection is understudied. Memory T cells generated during a primary influenza infection are important for protection against subsequent influenza exposures. Previously, we have demonstrated that diet-induced obese (DIO) mice have increased morbidity and mortality following secondary influenza infection compared with lean mice. To determine whether the problem resided in a failure to maintain functional, influenza-specific CD8(+) memory T cells, male DIO and lean mice were infected with influenza X-31. At 84 d postinfection, DIO mice had a 10% reduction in memory T cell numbers. This reduction may have resulted from significantly reduced memory T cell expression of interleukin 2 receptor beta (IL-2R beta, CD122), but not IL-7 receptor alpha (CD127), which are both required for memory cell maintenance. Peripheral leptin resistance in the DIO mice may be a contributing factor to the impairment. Indeed, leptin receptor mRNA expression was significantly reduced in the lungs of obese mice, whereas suppressor of cytokine signaling (Socs)1 and Socs3 mRNA expression were increased. It is imperative to understand how the obese state alters memory T cells, because impairment in maintenance of functional memory responses has important implications for vaccine efficacy in an obese population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  ISOLepr (Mus musculus)5129154; 5129154mRNA:decreased expression:lungRGD 
obesity  IEP 5129154mRNA:decreased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Lepr  (leptin receptor)

Genes (Mus musculus)
Lepr  (leptin receptor)

Genes (Homo sapiens)
LEPR  (leptin receptor)

Additional Information