RGD Reference Report - Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats. - Rat Genome Database

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Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats.

Authors: Horiuchi, H  Ogata, T  Morino, T  Yamamoto, H 
Citation: Horiuchi H, etal., Spinal Cord. 2010 Sep;48(9):685-90. Epub 2010 Jan 12.
RGD ID: 5129094
Pubmed: PMID:20065990   (View Abstract at PubMed)
DOI: DOI:10.1038/sc.2009.194   (Journal Full-text)

STUDY DESIGN: An in vivo study using a spinal cord compression model in rats. OBJECTIVES: To evaluate the effect of adenosine on thermal hyperalgesia after spinal cord injury (SCI).Summary of background data:After SCI, some patients suffer dysesthesia that is unresponsive to conventional treatments. We previously established a rat thoracic spinal cord mild-compression model by which we were able to induce thermal hyperalgesia in the hind limbs. METHODS: The thoracic spinal cord was compressed gently using a 20-g weight for 20 min. The withdrawal latency in response to thermal stimulation was monitored bilaterally in the hind limbs using Hargreaves' Plantar test apparatus. RESULTS: SCI-induced thermal hyperalgesia was mimicked by the intrathecal application of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist. Hyperalgesia induced by SCI was significantly inhibited by the intrathecal application of 10-30 nmol chloro-adenosine (Cl-adenosine), a nonselective adenosine receptor agonist. The effect of Cl-adenosine (10 nmol) on hyperalgesia after SCI was blocked by the simultaneous application of DPCPX. Intrathecal application of R(-)N6-(2phenylisopropyl) adenosine (R-PIA; 10 nmol), a selective A1 receptor agonist, also inhibited SCI-induced hyperalgesia. In contrast, intrathecal application of CGS21680, a selective adenosine A2a receptor agonist, did not inhibit SCI-induced hyperalgesia. CONCLUSIONS: These results suggest that adenosine inhibits hyperalgesia through the stimulation of A1 receptors. Adenosine or adenosine A1 receptor agonists should be considered as candidates for new therapeutic methods for treating post-SCI dysesthesia.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADORA1HumanHyperalgesia  ISOAdora1 (Rattus norvegicus)associated with Spinal Cord InjuriesRGD 
Adora1RatHyperalgesia  IDA associated with Spinal Cord InjuriesRGD 
Adora1MouseHyperalgesia  ISOAdora1 (Rattus norvegicus)associated with Spinal Cord InjuriesRGD 
Adora1RatSpinal Cord Injuries  IDA  RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Adora1Ratdetection of temperature stimulus involved in sensory perception of pain  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adora1  (adenosine A1 receptor)

Genes (Mus musculus)
Adora1  (adenosine A1 receptor)

Genes (Homo sapiens)
ADORA1  (adenosine A1 receptor)


Additional Information