RGD Reference Report - The mannose-binding lectin pathway is a significant contributor to reperfusion injury in the type 2 diabetic heart. - Rat Genome Database

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The mannose-binding lectin pathway is a significant contributor to reperfusion injury in the type 2 diabetic heart.

Authors: La Bonte, LR  Dokken, B  Davis-Gorman, G  Stahl, GL  McDonagh, PF 
Citation: La Bonte LR, etal., Diab Vasc Dis Res. 2009 Jul;6(3):172-80.
RGD ID: 4889154
Pubmed: PMID:20216929   (View Abstract at PubMed)
PMCID: PMC2834312   (View Article at PubMed Central)
DOI: DOI:10.1177/1479164109336051   (Journal Full-text)

The severity of ischaemic heart disease is markedly enhanced in type 2 diabetes. We recently reported that complement activation exacerbates I/R injury in the type 2 diabetic heart. The purpose of this study was to isolate and examine MBL pathway activation following I/R injury in the diabetic heart. ZLC and ZDF rats underwent 30 minutes of left coronary artery occlusion followed by 120 minutes of reperfusion. Two different groups of ZDF rats were treated with either FUT-175, a broad complement inhibitor, or P2D5, a monoclonal antibody raised against rat MBL-A. ZDF rats treated with FUT175 and P2D5 had significantly decreased myocardial infarct size, C3 deposition and neutrophil accumulation compared with untreated ZDF controls. Taken together, these findings indicate that the MBL pathway plays a key role in the severity of complement-mediated I/R injury in the type 2 diabetic heart.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Mbl1RatMyocardial Reperfusion Injury  IMP  RGD 
Mbl1MouseMyocardial Reperfusion Injury  ISOMbl1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl1  (mannose binding lectin 1)

Genes (Mus musculus)
Mbl1  (mannose-binding lectin (protein A) 1)


Additional Information