RGD Reference Report - FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis. - Rat Genome Database

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FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis.

Authors: Zhang, ZY  Zhang, Z  Schluesener, HJ 
Citation: Zhang ZY, etal., Neuropathol Appl Neurobiol. 2009 Oct;35(5):487-95. Epub 2009 Feb 4.
RGD ID: 4831923
Pubmed: PMID:19207263   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2990.2009.01016.x   (Journal Full-text)

AIMS: Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies. Here we have studied the spatiotemporal accumulation of interleukin (IL)-17(+) cells in sciatic nerves of EAN rats and effects of FTY720, an agonist of sphingosine-1-phosphate (S1P) receptors. METHODS: In this study, we examined the spatiotemporal expression of IL-17 using immunohistochemistry and RT-PCR, and analysed the IL-17(+) cell proportion in blood and lymph nodes using flow cytometry. RESULTS: In sciatic nerves of EAN rats, IL-17(+) cells were mainly found to concentrate around blood vessels and IL-17(+) cell accumulation was temporally correlated with severity of neurological signs. FTY720, which has been shown to reduce severity of EAN, attenuated accumulation of IL-17(+) cells in sciatic nerves, decreased IL-17(+) cell proportion in peripheral blood, but increased IL-17(+) cell proportion in lymph nodes, suggesting the involvement of S1P signal pathway in regulating IL-17(+) cell trafficking. CONCLUSIONS: our data are consistent with the possibility that IL-17(+) cells might contribute to the pathogenesis of EAN and the S1P signal pathway may be involved in the in vivo trafficking of IL-17(+) cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Neuritis  ISOIl17a (Rattus norvegicus)4831923; 4831923mRNA more ...RGD 
Experimental Autoimmune Neuritis  IEP 4831923mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il17a  (interleukin 17A)

Genes (Mus musculus)
Il17a  (interleukin 17A)

Genes (Homo sapiens)
IL17A  (interleukin 17A)

Additional Information