RGD Reference Report - Serum thymus and activation regulated chemokine levels post-lung transplantation as a predictor for the bronchiolitis obliterans syndrome. - Rat Genome Database

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Serum thymus and activation regulated chemokine levels post-lung transplantation as a predictor for the bronchiolitis obliterans syndrome.

Authors: Paantjens, AW  Kwakkel-van Erp, JM  Van Ginkel, WG  Van Kessel, DA  Van den Bosch, JM  Van de Graaf, EA  Otten, HG 
Citation: Paantjens AW, etal., Clin Exp Immunol. 2008 Nov;154(2):202-8. Epub 2008 Sep 8.
RGD ID: 4145604
Pubmed: PMID:18785972   (View Abstract at PubMed)
PMCID: PMC2612724   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1365-2249.2008.03764.x   (Journal Full-text)

The main reason for mortality after lung transplantation is the bronchiolitis obliterans syndrome (BOS), which represents chronic rejection. As soluble CD30, which is produced mainly by activated T helper 2 (Th2) cells, was shown to be related to development of BOS, we aimed to investigate the relation between development of BOS and Th2 chemoattractant thymus and activation regulated chemokine (TARC/CCL17). In 54 patients we measured serum TARC levels prior to transplantation by enzyme-linked immunosorbent assay, and in 44 of these patients sera were analysed at months 1, 2 and 3 after lung transplantation. In addition, longitudinal measurements were performed in sera from eight healthy controls and 14 patients, the latter taken over a period of 2 years post-transplantation from seven patients developing BOS plus seven clinically matched BOS-free patients. Median serum TARC levels post-transplantation of patients who developed BOS were significantly lower than those of the matched BOS-free patients (P = 0.05). A receiver operating characteristics analysis (area under the curve 0.77), together with a Kaplan-Meyer analysis, showed that serum TARC levels below 325 pg/ml in the first month post-transplantation can predict development of BOS post-transplantation (P = 0.001). In contrast, pretransplant serum TARC levels were not significantly different between patients developing BOS, BOS-free patients or healthy controls. In conclusion, pretransplantation serum TARC levels do not predict the development of BOS post-transplantation, but measurement of the serum TARC levels in the first month directly after transplantation can provide us with a tool to identify the group at risk of developing BOS.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL17Humanbronchiolitis obliterans  IEP  RGD 
Ccl17Ratbronchiolitis obliterans  ISOCCL17 (Homo sapiens) RGD 
Ccl17Mousebronchiolitis obliterans  ISOCCL17 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl17  (C-C motif chemokine ligand 17)

Genes (Mus musculus)
Ccl17  (C-C motif chemokine ligand 17)

Genes (Homo sapiens)
CCL17  (C-C motif chemokine ligand 17)


Additional Information