RGD Reference Report - Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat. - Rat Genome Database

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Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat.

Authors: Harony-Nicolas, Hala  Kay, Maya  du Hoffmann, Johann  Klein, Matthew E  Bozdagi-Gunal, Ozlem  Riad, Mohammed  Daskalakis, Nikolaos P  Sonar, Sankalp  Castillo, Pablo E  Hof, Patrick R  Shapiro, Matthew L  Baxter, Mark G  Wagner, Shlomo  Buxbaum, Joseph D 
Citation: Harony-Nicolas H, etal., Elife. 2017 Jan 31;6. doi: 10.7554/eLife.18904.
RGD ID: 41404704
Pubmed: PMID:28139198   (View Abstract at PubMed)
PMCID: PMC5283828   (View Article at PubMed Central)
DOI: DOI:10.7554/eLife.18904   (Journal Full-text)

Mutations in the synaptic gene SHANK3 lead to a neurodevelopmental disorder known as Phelan-McDermid syndrome (PMS). PMS is a relatively common monogenic and highly penetrant cause of autism spectrum disorder (ASD) and intellectual disability (ID), and frequently presents with attention deficits. The underlying neurobiology of PMS is not fully known and pharmacological treatments for core symptoms do not exist. Here, we report the production and characterization of a Shank3-deficient rat model of PMS, with a genetic alteration similar to a human SHANK3 mutation. We show that Shank3-deficient rats exhibit impaired long-term social recognition memory and attention, and reduced synaptic plasticity in the hippocampal-medial prefrontal cortex pathway. These deficits were attenuated with oxytocin treatment. The effect of oxytocin on reversing non-social attention deficits is a particularly novel finding, and the results implicate an oxytocinergic contribution in this genetically defined subtype of ASD and ID, suggesting an individualized therapeutic approach for PMS.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Objects Annotated

Genes (Rattus norvegicus)
Shank3  (SH3 and multiple ankyrin repeat domains 3)
Shank3em1Bux  (SH3 and multiple ankyrin repeat domains 3; ZFN induced mutant 1, Bux)

Genes (Mus musculus)
Shank3  (SH3 and multiple ankyrin repeat domains 3)

Genes (Homo sapiens)
SHANK3  (SH3 and multiple ankyrin repeat domains 3)

Strains
SD-Shank3em1Bux  (NA)


Additional Information