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PhysGen Knockouts

Authors: JACOB,   Howard, J 
Citation: PhysGen Knockout strains
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Dr. Jacob received a 2 year, ARRA funded, grant from NHLBI to refine a new methodology for site directed mutagenesis in the rat. Zinc finger nucleases are being used to knock out a large number of genes involved with hypertensive, genetically susceptible and normotensive rat strains. The overall goal is to use this novel technique to knockout genes in hypertensive and normotensive animal models to test the role of these genes in the vascular and renal mechanisms controlling blood pressure.


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Additional Information

RGD Object Information
RGD ID: 4139871
Created: 2010-08-20
Species: All species
Last Modified: 2010-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.