RGD Reference Report - Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo. - Rat Genome Database

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Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo.

Authors: Allen, Sariah J  Mott, Kevin R  Ghiasi, Homayon 
Citation: Allen SJ, etal., Exp Eye Res. 2014 Jun;123:8-15. doi: 10.1016/j.exer.2014.04.004. Epub 2014 Apr 24.
RGD ID: 40903051
Pubmed: PMID:24768597   (View Abstract at PubMed)
PMCID: PMC4047190   (View Article at PubMed Central)
DOI: DOI:10.1016/j.exer.2014.04.004   (Journal Full-text)

Recently we have shown that the highly conserved herpes simplex virus glycoprotein K (gK) binds to signal peptide peptidase (SPP), also known as minor histocompatibility antigen H13. In this study we have demonstrated for the first time that inhibitors of SPP, such as L685,458, (Z-LL)2 ketone, aspirin, ibuprofen and DAPT, significantly reduced HSV-1 replication in tissue culture. Inhibition of SPP activity via (Z-LL)2 ketone significantly reduced viral transcripts in the nucleus of infected cells. Finally, when administered during primary infection, (Z-LL)2 ketone inhibitor reduced HSV-1 replication in the eyes of ocularly infected mice. Thus, blocking SPP activity may represent a clinically effective and expedient approach to the reduction of viral replication and the resulting pathology.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
H13MouseHerpesviridae Infections treatmentIMP  RGD 
HM13HumanHerpesviridae Infections treatmentISORGD:1319014 RGD 
Hm13RatHerpesviridae Infections treatmentISORGD:1319014 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hm13  (histocompatibility minor 13)

Genes (Mus musculus)
H13  (histocompatibility 13)

Genes (Homo sapiens)
HM13  (histocompatibility minor 13)


Additional Information