RGD Reference Report - Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome. - Rat Genome Database

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Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome.

Authors: Altmäe, Signe  Segura, Maria Teresa  Esteban, Francisco J  Bartel, Sabine  Brandi, Pilar  Irmler, Martin  Beckers, Johannes  Demmelmair, Hans  López-Sabater, Carmen  Koletzko, Berthold  Krauss-Etschmann, Susanne  Campoy, Cristina 
Citation: Altmäe S, etal., PLoS One. 2017 Jan 26;12(1):e0169223. doi: 10.1371/journal.pone.0169223. eCollection 2017.
RGD ID: 40902990
Pubmed: PMID:28125591   (View Abstract at PubMed)
PMCID: PMC5268451   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0169223   (Journal Full-text)

Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes. However, the molecular mechanisms underlying these processes are poorly understood. We analysed ten term placenta's whole transcriptomes in obese (n = 5) and normal weight women (n = 5), using the Affymetrix microarray platform. Analyses of expression data were carried out using non-parametric methods. Hierarchical clustering and principal component analysis showed a clear distinction in placental transcriptome between obese and normal weight women. We identified 72 differentially regulated genes, with most being down-regulated in obesity (n = 61). Functional analyses of the targets using DAVID and IPA confirm the dysregulation of previously identified processes and pathways in the placenta from obese women, including inflammation and immune responses, lipid metabolism, cancer pathways, and angiogenesis. In addition, we detected new molecular aspects of obesity-derived effects on the placenta, involving the glucocorticoid receptor signalling pathway and dysregulation of several genes including CCL2, FSTL3, IGFBP1, MMP12, PRG2, PRL, QSOX1, SERPINE2 and TAC3. Our global gene expression profiling approach demonstrates that maternal obesity creates a unique in utero environment that impairs the placental transcriptome.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PRG2Humanobesity  HEP mRNA:decreased expression:placenta (human)RGD 

Objects Annotated

Genes (Homo sapiens)
PRG2  (proteoglycan 2, pro eosinophil major basic protein)


Additional Information