RGD Reference Report - Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation.

Authors: Artis, David  Shapira, Sagi  Mason, Nicola  Speirs, Kendra M  Goldschmidt, Michael  Caamaño, Jorge  Liou, Hsiou-Chi  Hunter, Christopher A  Scott, Phillip 
Citation: Artis D, etal., J Immunol. 2002 Oct 15;169(8):4481-7. doi: 10.4049/jimmunol.169.8.4481.
RGD ID: 40902988
Pubmed: PMID:12370384   (View Abstract at PubMed)
DOI: DOI:10.4049/jimmunol.169.8.4481   (Journal Full-text)

The NF-kappaB family of transcription factors is critical in controlling the expression of a wide range of immune response genes. However, whether individual family members perform specific roles in regulating immunity and inflammation remains unclear. Here we investigated the requirement for NF-kappaB1, NF-kappaB2, and c-Rel in the expression of Th2 cytokine responses, development of host protective immunity, and regulation of intestinal inflammation following infection with the gut-dwelling helminth parasite Trichuris muris. While mice deficient in c-Rel mounted sufficient Th2 responses to expel infection, NF-kappaB1 knockout (KO) and NF-kappaB2 KO mice developed chronic infections associated with elevated production of Ag-specific IFN-gamma. However, only infected NF-kappaB1 KO mice exhibited polarized IFN-gamma responses associated with the loss of intestinal goblet cells and the development of destructive colitis-like pathology. Furthermore, blockade of IL-12 (previously shown to confer resistance in susceptible strains) recovered Ag-specific IL-13 responses and resistance to infection in NF-kappaB2 KO, but not NF-kappaB1 KO mice. Therefore, unique infection, immunological, and pathological outcomes were observed in different NF-kappaB KO strains. Taken together, these results provide direct evidence of nonoverlapping functions for NF-kappaB family members in the development of Th2 cytokine-mediated resistance to T. muris and the control of infection-induced intestinal inflammation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NFKB1HumanIntestinal Helminthiasis disease_progressionISONfkb1 (Mus musculus) RGD 
NFKB2HumanIntestinal Helminthiasis treatmentISONfkb2 (Mus musculus) RGD 
Nfkb1RatIntestinal Helminthiasis disease_progressionISONfkb1 (Mus musculus) RGD 
Nfkb1MouseIntestinal Helminthiasis disease_progressionIMP  RGD 
Nfkb2RatIntestinal Helminthiasis treatmentISONfkb2 (Mus musculus) RGD 
Nfkb2MouseIntestinal Helminthiasis treatmentIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nfkb1  (nuclear factor kappa B subunit 1)
Nfkb2  (nuclear factor kappa B subunit 2)

Genes (Mus musculus)
Nfkb1  (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105)
Nfkb2  (nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100)

Genes (Homo sapiens)
NFKB1  (nuclear factor kappa B subunit 1)
NFKB2  (nuclear factor kappa B subunit 2)


Additional Information