RGD Reference Report - Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. - Rat Genome Database

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Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients.

Authors: Luo, Rui  Li, Xingyuan  Qin, Shasha  Luo, Zhenzhou  Luo, Xi  Hu, Peiwu  Liu, Zhisheng  Feng, Xiangling  Li, Xingli 
Citation: Luo R, etal., Pharmacogenomics. 2017 Dec;18(18):1659-1670. doi: 10.2217/pgs-2017-0072. Epub 2017 Nov 27.
RGD ID: 401976557
Pubmed: PMID:29173032   (View Abstract at PubMed)
DOI: DOI:10.2217/pgs-2017-0072   (Journal Full-text)


AIM: To evaluate the potential association of the genetic polymorphisms in ABCB1, ARRB2, DRD1 and OPRD1 genes with methadone dosage requirement among Han Chinese opioid-dependent patients.
MATERIALS & METHODS: Eight SNPs in ABCB1, ARRB2, DRD1 and OPRD1 genes were selected and genotyped using Sequenom MassARRAY platform among 257 methadone maintenance treatment patients. The required information about stable methadone dose, urine analysis for opioid and socio-demographic characteristics was collected. Generalized multifactor dimensionality reduction method was performed to analyze the SNP-SNP interaction.
RESULTS: We found that patients carrying the rs529520TG genotype of OPRD1 probably required higher methadone treatment dosage. A 3-locus SNP-SNP interaction pattern (rs1128503 in ABCB1, rs529520 in OPRD1 and rs1045280 in ARRB2) was significantly associated with the methadone dosage requirement (p = 0.029).
CONCLUSION: Our results suggested that specific OPRD1 variants and interaction among polymorphisms in ABCB1, OPRD1 and ARRB2 genes contributes to methadone dosage requirement in Han Chinese opioid-dependent patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ABCB1Humanheroin dependence treatmentIAGP associated with methadone treatment;DNA:SNP:intron (rs1128503) (human)RGD 
ARRB2Humanheroin dependence treatmentIAGP associated with methadone treatment;DNA:SNP:intron (rs1045280) (human)RGD 
Abcb1aRatheroin dependence treatmentISOABCB1 (Homo sapiens)associated with methadone treatment;DNA:SNP:intron (rs1128503) (human)RGD 
Abcb1aMouseheroin dependence treatmentISOABCB1 (Homo sapiens)associated with methadone treatment;DNA:SNP:intron (rs1128503) (human)RGD 
Arrb2Ratheroin dependence treatmentISOARRB2 (Homo sapiens)associated with methadone treatment;DNA:SNP:intron (rs1045280) (human)RGD 
Arrb2Mouseheroin dependence treatmentISOARRB2 (Homo sapiens)associated with methadone treatment;DNA:SNP:intron (rs1045280) (human)RGD 
OPRD1Humanheroin dependence treatmentIAGP associated with methadone treatment;DNA:SNP:intron (rs529520) (human)RGD 
Oprd1Ratheroin dependence treatmentISOOPRD1 (Homo sapiens)associated with methadone treatment;DNA:SNP:intron (rs529520) (human)RGD 
Oprd1Mouseheroin dependence treatmentISOOPRD1 (Homo sapiens)associated with methadone treatment;DNA:SNP:intron (rs529520) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ABCB1HumanAmeliorated by exposure to medication treatmentIAGP associated with methadone treatment;DNA:SNP:intron (rs1128503) (human)RGD 
ARRB2HumanAmeliorated by exposure to medication treatmentIAGP associated with methadone treatment;DNA:SNP:intron (rs1045280) (human)RGD 
OPRD1HumanAmeliorated by exposure to medication treatmentIAGP associated with methadone treatment;DNA:SNP:intron (rs529520) (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Abcb1a  (ATP binding cassette subfamily B member 1A)
Arrb2  (arrestin, beta 2)
Oprd1  (opioid receptor, delta 1)

Genes (Mus musculus)
Abcb1a  (ATP-binding cassette, sub-family B member 1A)
Arrb2  (arrestin, beta 2)
Oprd1  (opioid receptor, delta 1)

Genes (Homo sapiens)
ABCB1  (ATP binding cassette subfamily B member 1)
ARRB2  (arrestin beta 2)
OPRD1  (opioid receptor delta 1)


Additional Information