RGD Reference Report - Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall. - Rat Genome Database

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Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.

Authors: Liu, Xiaoping  El-Mahdy, Mohamed A  Boslett, James  Varadharaj, Saradhadevi  Hemann, Craig  Abdelghany, Tamer M  Ismail, Raed S  Little, Sean C  Zhou, Danlei  Thuy, Le Thi Thanh  Kawada, Norifumi  Zweier, Jay L 
Citation: Liu X, etal., Nat Commun. 2017 Apr 10;8:14807. doi: 10.1038/ncomms14807.
RGD ID: 401901230
Pubmed: PMID:28393874   (View Abstract at PubMed)
PMCID: PMC5394235   (View Article at PubMed Central)
DOI: DOI:10.1038/ncomms14807   (Journal Full-text)

The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O2-dependent NO degradation in smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates the rate of NO consumption by metabolizing NO in an O2-dependent manner with decreased NO consumption in physiological hypoxia. Here we show that Cygb is a major regulator of NO degradation and cardiovascular tone. Knockout of Cygb greatly prolongs NO decay, increases vascular relaxation, and lowers blood pressure and systemic vascular resistance. We further demonstrate that downregulation of Cygb prevents angiotensin-mediated hypertension. Thus, Cygb has a critical role in the regulation of vascular tone and disease. We suggest that modulation of the expression and NOD activity of Cygb represents a strategy for the treatment of cardiovascular disease.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CygbRatnitric oxide catabolic process involved_inIMP PMID:28393874UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CygbRatnitric oxide dioxygenase activity, heme protein as donor enablesIDA PMID:28393874UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Cygb  (cytoglobin)


Additional Information