RGD Reference Report - IFN-beta suppresses experimental autoimmune neuritis in Lewis rats by inhibiting the migration of inflammatory cells into peripheral nervous tissue. - Rat Genome Database

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IFN-beta suppresses experimental autoimmune neuritis in Lewis rats by inhibiting the migration of inflammatory cells into peripheral nervous tissue.

Authors: Zou, L P  Ma, D H  Wei, L  van der Meide, P H  Mix, E  Zhu, J 
Citation: Zou LP, etal., J Neurosci Res. 1999 Apr 15;56(2):123-30. doi: 10.1002/(sici)1097-4547(19990415)56:2<123::aid-jnr2>3.0.co;2-g.
RGD ID: 401854240
Pubmed: PMID:10494101   (View Abstract at PubMed)
DOI: DOI:10.1002/(sici)1097-4547(19990415)56:2<123::aid-jnr2>3.0.co;2-g   (Journal Full-text)

The putative prophylactic and therapeutic effect of interferon-beta (IFN-beta) on autoimmune inflammation of the peripheral nervous system was evaluated in experimental autoimmune neuritis (EAN), a well-known animal model of the human Guillain-Barré syndrome (GBS). We report that treatment of rats with 300,000 U of recombinant rat IFN-beta (rrIFN-beta) given every other day starting at the day of immunization prevented clinical signs of EAN. When treatment was started at the onset of disease development, the cytokine clearly ameliorated EAN. Both B- and T-cell responses towards peripheral myelin were suppressed by the IFN-beta, and immunohistochemical analyses revealed a strong decrease in the numbers of infiltrating CD4(+) T cells, macrophages, and other inflammatory cells as well as a significant reduction in MHC class II antigen expression and monocyte chemotactic protein-1 (MCP-1) production, which induces chemotaxis and chemokinesis of leukocytes from blood. It is concluded that the observed suppression of EAN by rrIFN-beta is associated with a decrease in the migration of inflammatory cells into peripheral nervous tissue.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Neuritis amelioratesISOIfnb1 (Rattus norvegicus)401854240; 401854240 RGD 
Experimental Autoimmune Neuritis amelioratesIDA 401854240 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Ifnb1  (interferon beta 1)

Genes (Mus musculus)
Ifnb1  (interferon beta 1, fibroblast)

Genes (Homo sapiens)
IFNB1  (interferon beta 1)


Additional Information