RGD Reference Report - Type I IFN-beta gene therapy suppresses cardiac CD8+ T-cell infiltration during autoimmune myocarditis. - Rat Genome Database

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Type I IFN-beta gene therapy suppresses cardiac CD8+ T-cell infiltration during autoimmune myocarditis.

Authors: Bartlett, Emmalene J  Lenzo, Jason C  Sivamoorthy, Soruba  Mansfield, Josephine P  Cull, Vanessa S  James, Cassandra M 
Citation: Bartlett EJ, etal., Immunol Cell Biol. 2004 Apr;82(2):119-26. doi: 10.1046/j.0818-9641.2004.01234.x.
RGD ID: 401851923
Pubmed: PMID:15061762   (View Abstract at PubMed)
DOI: DOI:10.1046/j.0818-9641.2004.01234.x   (Journal Full-text)

Gene therapy using DNA encoding type I IFN subtypes IFNA6, IFNA9 and IFNB suppresses murine cytomegalovirus (MCMV)-myocarditis, a predominantly cell-mediated disease in BALB/c mice. CD8(+) T cells are the principal cell type within the inflamed myocardium. As such, we investigated the effects of IFN subtype treatment on this T-cell subset and other cell types in the cardiac infiltrate. In the acute phase of disease, IFNA6 and IFNA9 treatments significantly reduced the number of CD8(+) T cells within the foci of cellular infiltration in the heart. During the chronic phase, which is primarily autoimmune in nature, IFNB treatment significantly reduced CD8(+) T cells. B-cell and neutrophil numbers in the cardiac infiltrate were also reduced following IFNB immunotherapy. Although early inflammatory responses are important for resolution of virus infection, high numbers of lymphocytes persisting in the myocardium may lead to exacerbation of disease. Our data suggests that type I IFN DNA therapy regulates cardiac cellular infiltration. Thus, treatment with IFN-beta administered prophylactically to high-risk patients in acquiring CMV infection may reduce the development of chronic autoimmune myocarditis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autoimmune myocarditis amelioratesISOIfnb1 (Mus musculus)401851923; 401851923 RGD 
autoimmune myocarditis amelioratesIDA 401851923 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifnb1  (interferon beta 1)

Genes (Mus musculus)
Ifnb1  (interferon beta 1, fibroblast)

Genes (Homo sapiens)
IFNB1  (interferon beta 1)

Additional Information