RGD Reference Report - Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells. - Rat Genome Database

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Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells.

Authors: Mitchell, J L  Judd, G G  Bareyal-Leyser, A  Ling, S Y 
Citation: Mitchell JL, etal., Biochem J. 1994 Apr 1;299 ( Pt 1)(Pt 1):19-22. doi: 10.1042/bj2990019.
RGD ID: 401851045
Pubmed: PMID:8166639   (View Abstract at PubMed)
PMCID: PMC1138014   (View Article at PubMed Central)
DOI: DOI:10.1042/bj2990019   (Journal Full-text)

Antizyme, a spermidine-induced protein that binds and stimulates ornithine decarboxylase degradation, is now shown also to mediate the rapid feedback inhibition of polyamine uptake into mammalian cells. Using a cell line (HZ7) transfected with truncated antizyme cDNA, and mutant ornithine decarboxylase cell lines, we demonstrate that this newly discovered action of antizyme is distinct from its role in modulating polyamine biosynthesis.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Oaz1Ratcellular response to polyamine macromolecule  IDA spermidineRGD 
Oaz1Ratnegative regulation of ornithine catabolic process  IDA  RGD 
Oaz1Ratnegative regulation of polyamine transmembrane transport  IMP spermidineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Oaz1  (ornithine decarboxylase antizyme 1)


Additional Information