RGD Reference Report - Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. - Rat Genome Database

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Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats.

Authors: Assayed, Mohamed E 
Citation: Assayed ME, Immunopharmacol Immunotoxicol. 2010 Jun;32(2):284-96. doi: 10.3109/08923970903307552.
RGD ID: 401827914
Pubmed: PMID:20105084   (View Abstract at PubMed)
DOI: DOI:10.3109/08923970903307552   (Journal Full-text)


BACKGROUND AND AIM: Sixty male Wistar rats, divided into 4 groups, 15 each, were designed as I-control rats, II-rats orally intubated with Nigella sativa oil (1 ml/kg b.wt./day) for 5 days/week, III-whole body gamma irradiated rats with the estimated LD50/30 (4 Gray) and IV-rats daily intubated with Nigella sativa oil then subjected to whole body gamma irradiation, to investigate the radioprotective potential of Nigella crude oil against hemopoietic adverse effects of gamma irradiation.
RESULTS: Irradiation resulted in significant reduction in hemolysin antibodies titers and delayed type hypersensitivity reaction of irradiated rats, in addition to significant leukopenia and significant decrease in plasma total protein and globulin concentrations and depletion of lymphoid follicles of spleen and thymus gland. Furthermore, there was a significant increase in malondialdehyde concentration with a significant decrease in plasma glutathione peroxidase, catalase and erythrocyte superoxide dismutase activities were recorded. Oral administration of Nigella sativa oil before irradiation considerably normalized all the above-mentioned criteria; and produced significant regeneration in spleen and thymus lymphoid follicles.
CONCLUSION: Our results strongly recommend Nigella sativa oil as a promising natural radioprotective agent against immunosuppressive and oxidative effects of ionizing radiation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GPX3HumanRadiation Injuries treatmentISOGpx3 (Rattus norvegicus) RGD 
Gpx3RatRadiation Injuries treatmentIEP  RGD 
Gpx3MouseRadiation Injuries treatmentISOGpx3 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gpx3  (glutathione peroxidase 3)

Genes (Mus musculus)
Gpx3  (glutathione peroxidase 3)

Genes (Homo sapiens)
GPX3  (glutathione peroxidase 3)


Additional Information