RGD Reference Report - Emerging roles of CCM genes during tumorigenesis with potential application as novel biomarkers across major types of cancers. - Rat Genome Database

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Emerging roles of CCM genes during tumorigenesis with potential application as novel biomarkers across major types of cancers.

Authors: Abou-Fadel, Johnathan  Qu, Yanchun  Gonzalez, Elias M  Smith, Mark  Zhang, Jun 
Citation: Abou-Fadel J, etal., Oncol Rep. 2020 Jun;43(6):1945-1963. doi: 10.3892/or.2020.7550. Epub 2020 Mar 18.
RGD ID: 401827111
Pubmed: PMID:32186778   (View Abstract at PubMed)
PMCID: PMC7160551   (View Article at PubMed Central)
DOI: DOI:10.3892/or.2020.7550   (Journal Full-text)

Cerebral cavernous malformations (CCMs) are microvascular anomalies in the brain that result in increased susceptibility to stroke. Three genes have been identified as causes of CCMs: cerebral cavernous malformations 1 [(CCM1) also termed Krev interaction trapped 1 (KRIT1)], cerebral cavernous malformation 2 [(CCM2) also termed MGC4607] and cerebral cavernous malformation 3 [(CCM3) also termed programmed cell death 10 (PDCD10)]. It has been demonstrated that both CCM1 and CCM3 bind to CCM2 to form a CCM signaling complex (CSC) with which to modulate multiple signaling cascades. CCM proteins have been reported to play major roles in microvascular angiogenesis in human and animal models. However, CCM proteins are ubiquitously expressed in all major tissues, suggesting an unseen broader role of the CSC in biogenesis. Recent evidence suggests the possible involvement of the CSC complex during tumorigenesis; however, studies concerning this aspect are limited. This is the first report to systematically investigate the expression patterns of CCM proteins in major human tumors using real‑time quantitative PCR, RNA‑fluorescence in situ hybridization, immunohistochemistry and multicolor immunofluorescence imaging. Our data demonstrated that differential expression patterns of the CSC complex are correlated with certain types and grades of major human cancers, indicating the potential application of CCM genes as molecular biomarkers for clinical oncology. Our data strongly suggest that more efforts are needed to elucidate the role of the CSC complex in tumorigenesis, which may have enormous clinical potential for cancer diagnostic, prognostic and therapeutic applications.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PDCD10Humanendometrial adenocarcinoma disease_progressionIEP protein:increased expression:endometrium (human)RGD 
Pdcd10Ratendometrial adenocarcinoma disease_progressionISOPDCD10 (Homo sapiens)protein:increased expression:endometrium (human)RGD 
Pdcd10Mouseendometrial adenocarcinoma disease_progressionISOPDCD10 (Homo sapiens)protein:increased expression:endometrium (human)RGD 
PDCD10Humanhepatitis  IEP protein:increased expression:liver (human)RGD 
Pdcd10Rathepatitis  ISOPDCD10 (Homo sapiens)protein:increased expression:liver (human)RGD 
Pdcd10Mousehepatitis  ISOPDCD10 (Homo sapiens)protein:increased expression:liver (human)RGD 
PDCD10Humanliver carcinoma  IEP protein:increased expression:liver (human)RGD 
Pdcd10Ratliver carcinoma  ISOPDCD10 (Homo sapiens)protein:increased expression:liver (human)RGD 
Pdcd10Mouseliver carcinoma  ISOPDCD10 (Homo sapiens)protein:increased expression:liver (human)RGD 
PDCD10Humanliver cirrhosis  IEP protein:increased expression:liver (human)RGD 
Pdcd10Ratliver cirrhosis  ISOPDCD10 (Homo sapiens)protein:increased expression:liver (human)RGD 
Pdcd10Mouseliver cirrhosis  ISOPDCD10 (Homo sapiens)protein:increased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdcd10  (programmed cell death 10)

Genes (Mus musculus)
Pdcd10  (programmed cell death 10)

Genes (Homo sapiens)
PDCD10  (programmed cell death 10)


Additional Information