RGD Reference Report - Regulatory peptides in the plasma of patients with chronic cardiac failure at rest and during exercise. - Rat Genome Database

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Regulatory peptides in the plasma of patients with chronic cardiac failure at rest and during exercise.

Authors: Nicholls, D P  Riley, M  Elborn, J S  Stanford, C F  Shaw, C  McKillop, J M  Buchanan, K D 
Citation: Nicholls DP, etal., Eur Heart J. 1992 Oct;13(10):1399-404. doi: 10.1093/oxfordjournals.eurheartj.a060073.
RGD ID: 401700398
Pubmed: PMID:1396815   (View Abstract at PubMed)
DOI: DOI:10.1093/oxfordjournals.eurheartj.a060073   (Journal Full-text)

The levels of several regulatory peptides were measured in peripheral plasma samples from individuals with chronic cardiac failure (CCF) and matched controls in both the resting state and during a short period of maximal exercise. Basal levels of noradrenaline (NA; 705 +/- 114 vs 195 +/- 54 ng.l-1; mean +/- SEM; P < 0.05), plasma renin activity (PRA; 12.9 +/- 2.9 vs 2.1 +/- 0.3 ng AI ml-1.h-1; P < 0.05) and aldosterone (ALDO; 325 +/- 49 vs 87 +/- 8 ng.l-1; P < 0.05) were all raised in the patients with CCF, and increased further with exercise. Basal circulating levels of atrial natriuretic peptide (ANP) were also significantly higher in the CCF group compared to controls (136 +/- 35 vs 27 +/- 5 ng.l-1; P < 0.01), but the response to exercise was attenuated, so that at peak exercise, no significant difference was observed. Basal circulating levels of gastrin-releasing peptide (GRP) (29 +/- 4 vs 40 +/- 4 ng.l-1; P < 0.05) and secretin (13 +/- 1 vs 32 +/- 4 ng.l-1; P < 0.05) were significantly lower in the CCF group when compared to controls and there was no significant change in the levels of either peptide with exercise. Levels of neurokinin A (NKA), neuropeptide Y (NPY) and neurotensin (NT) were somewhat higher in patients, but the differences were not significant, and there were no changes during exercise. There were also no significant differences in the levels of vasoactive intestinal peptide (VIP), glucose-dependent insulinotropic polypeptide (GIP), insulin or glucagon in either experimental group both before and during exercise. We have therefore identified different circulating levels of certain regulatory peptides in patients with CCF, but the significance of these remains unclear.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GRPHumancongestive heart failure  IEP protein:decreased expression:plasma (human)RGD 
GrpRatcongestive heart failure  ISOGRP (Homo sapiens)protein:decreased expression:plasma (human)RGD 
GrpMousecongestive heart failure  ISOGRP (Homo sapiens)protein:decreased expression:plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grp  (gastrin releasing peptide)

Genes (Mus musculus)
Grp  (gastrin releasing peptide)

Genes (Homo sapiens)
GRP  (gastrin releasing peptide)


Additional Information