RGD Reference Report - Clinical Application of Pro-Gastrin-Releasing Peptide. - Rat Genome Database

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Clinical Application of Pro-Gastrin-Releasing Peptide.

Authors: Fang, Lili  Huang, Zhongqiang  Lin, Yongzhi  Fu, Jianguo  Liang, Xianming  Liu, Fan 
Citation: Fang L, etal., Clin Lab. 2018 Jul 1;64(7):1259-1268. doi: 10.7754/Clin.Lab.2018.180316.
RGD ID: 401700396
Pubmed: PMID:30146822   (View Abstract at PubMed)
DOI: DOI:10.7754/Clin.Lab.2018.180316   (Journal Full-text)


BACKGROUND: The diagnostic sensitivity and specificity of serum Pro-gastrin-releasing peptide (ProGRP) in benign or malignant diseases remains controversial.
METHODS: The clinical data of 6,948 patients who were examined for ProGRP from February 2015 to January 2017 in the Zhongshan Hospital of the XiaMen University, were collected. The clinical data of the different groups were analyzed by statistical methods.
RESULTS: The ProGRP reference levels were 68.50 pg/mL. The percentages of abnormal ProGRP levels were 23.87%, 26.14%, 22.87%, 84.56%, 16.1%, 15.59% and 43.75% for the pneumonia, cardiovascular disease, cerebral vascular disease, renal failure, small cell lung cancer (SCLC), colorectal cancer, and prostate cancer groups, respectively. The 95th percentile of the serum ProGRP concentration levels in the renal failure group was 364.22 pg/mL. The ProGRP cutoff levels for SCLC group were 162.90 pg/mL and the area under the receiver-operating characteristic curve (AUC) was 0.940 (95% CI, 0.892 to 0.987). The parameters sensitivity, specificity, PLR (positive likelihood ratio), NLR (negative likelihood) and Kappa value for the SCLC group with the exclusion of the renal failure group were 81.10% (95% CI: 38.19% - 89.71%), 99.51% (95% CI: 99.31% - 99.66%), 167.59 (95% CI: 116.06 - 241.99), 0.19 (95% CI: 0.11 - 0.32), and 0.6830 (Sig: 0.000), respectively. In the SCLC group, significantly higher concentrations of serum ProGRP of M1 were observed compared with M0. All esophageal neoplasms with high-level ProGRP were identified as small cell neoplasms.
CONCLUSIONS: The ProGRP levels were increased in a variety of benign and malignant diseases and were considered a putative marker for SCLC with the exception of the renal failure group. It may be suggested that the high ProGRP levels originated from patients with neuroendocrine tumor.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GRPHumancerebrovascular disease  IEP protein:increased expression:serum (human)RGD 
GrpRatcerebrovascular disease  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GrpMousecerebrovascular disease  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GRPHumancolorectal cancer  IEP protein:increased expression:serum (human)RGD 
GrpRatcolorectal cancer  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GrpMousecolorectal cancer  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GRPHumankidney failure  IEP protein:increased expression:serum (human)RGD 
GrpRatkidney failure  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GrpMousekidney failure  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GRPHumanlung non-small cell carcinoma disease_progressionIEP protein:increased expression:serum (human)RGD 
GrpRatlung non-small cell carcinoma disease_progressionISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GrpMouselung non-small cell carcinoma disease_progressionISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GRPHumanlung small cell carcinoma disease_progressionIEP protein:increased expression:serum (human)RGD 
GrpRatlung small cell carcinoma disease_progressionISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GrpMouselung small cell carcinoma disease_progressionISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GRPHumanpneumonia  IEP protein:increased expression:serum (human)RGD 
GrpRatpneumonia  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GrpMousepneumonia  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GRPHumanprostate cancer  IEP protein:increased expression:serum (human)RGD 
GrpRatprostate cancer  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 
GrpMouseprostate cancer  ISOGRP (Homo sapiens)protein:increased expression:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grp  (gastrin releasing peptide)

Genes (Mus musculus)
Grp  (gastrin releasing peptide)

Genes (Homo sapiens)
GRP  (gastrin releasing peptide)


Additional Information