RGD Reference Report - SIGN-R1 contributes to protection against lethal pneumococcal infection in mice. - Rat Genome Database

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SIGN-R1 contributes to protection against lethal pneumococcal infection in mice.

Authors: Lanoue, Astrid  Clatworthy, Menna R  Smith, Philippa  Green, Sheila  Townsend, Michael J  Jolin, Helen E  Smith, Kenneth G C  Fallon, Padraic G  McKenzie, Andrew N J 
Citation: Lanoue A, etal., J Exp Med. 2004 Dec 6;200(11):1383-93. doi: 10.1084/jem.20040795.
RGD ID: 39939009
Pubmed: PMID:15583012   (View Abstract at PubMed)
PMCID: PMC2211941   (View Article at PubMed Central)
DOI: DOI:10.1084/jem.20040795   (Journal Full-text)

Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesting a role for SIGN-R1 in this process. We now demonstrate that mice lacking SIGN-R1 (a mouse homologue of human dendritic cell-SIGN receptor) are significantly more susceptible to Streptococcus pneumoniae infection and fail to clear S. pneumoniae from the circulation. Marginal zone and peritoneal macrophages show impaired bacterial recognition associated with an inability to bind T-independent type 2 antigens such as dextran. Our work represents the first evidence for a protective in vivo role for a SIGN family molecule.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cd209bMouseSeptic Peritonitis susceptibilityIMP  RGD 
Clec4mRatSeptic Peritonitis susceptibilityISOCd209b (Mus musculus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Clec4m  (C-type lectin domain family 4 member M)

Genes (Mus musculus)
Cd209b  (CD209b antigen)

Objects referenced in this article
Gene Cd209a CD209a antigen Mus musculus
Gene Cd209a CD209a molecule Rattus norvegicus

Additional Information