RGD Reference Report - CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology. - Rat Genome Database

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CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology.

Authors: Kalantari, Parisa  Morales, Yoelkys  Miller, Emily A  Jaramillo, Luis D  Ponichtera, Holly E  Wuethrich, Marcel A  Cheong, Cheolho  Seminario, Maria C  Russo, Joanne M  Bunnell, Stephen C  Stadecker, Miguel J 
Citation: Kalantari P, etal., Cell Rep. 2018 Jan 30;22(5):1288-1300. doi: 10.1016/j.celrep.2018.01.001.
RGD ID: 39938990
Pubmed: PMID:29386115   (View Abstract at PubMed)
PMCID: PMC5815841   (View Article at PubMed Central)
DOI: DOI:10.1016/j.celrep.2018.01.001   (Journal Full-text)

The immunopathology caused by schistosome helminths varies greatly in humans and among mouse strains. A severe form of parasite egg-induced hepatic granulomatous inflammation, seen in CBA mice, is driven by Th17 cells stimulated by IL-1β and IL-23 produced by dendritic cells that express CD209a (SIGNR5), a C-type lectin receptor (CLR) related to human DC-SIGN. Here, we show that CD209a-deficient CBA mice display decreased Th17 responses and are protected from severe immunopathology. In vitro, CD209a augments the egg-induced IL-1β and IL-23 production initiated by the related CLRs Dectin-2 and Mincle. While Dectin-2 and Mincle trigger an FcRγ-dependent signaling cascade that involves the tyrosine kinase Syk and the trimolecular Card9-Bcl10-Malt1 complex, CD209a promotes the sustained activation of Raf-1. Our findings demonstrate that CD209a drives severe Th17 cell-mediated immunopathology in a helminthic disease based on synergy between DC-SIGN- and Dectin-2-related CLRs.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cd209aRathepatosplenic schistosomiasis  ISOCd209a (Mus musculus) RGD 
Cd209aMousehepatosplenic schistosomiasis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd209a  (CD209a molecule)

Genes (Mus musculus)
Cd209a  (CD209a antigen)


Additional Information