RGD Reference Report - Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection.

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Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection.
Authors:	Koppel, Estella A Wieland, Catharina W van den Berg, Venice C M Litjens, Manja Florquin, Sandrine van Kooyk, Yvette van der Poll, Tom Geijtenbeek, Teunis B H
Citation:	Koppel EA, etal., Eur J Immunol. 2005 Oct;35(10):2962-9. doi: 10.1002/eji.200526216.
RGD ID:	39938986
Pubmed:	PMID:16134084 (View Abstract at PubMed)
DOI:	DOI:10.1002/eji.200526216 (Journal Full-text)
The dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) homolog, SIGN-related 1 (SIGNR1) is a pathogen receptor expressed by splenic marginal zone and peritoneal macrophages, and is essential for clearance of Streptococcus pneumoniae by phagocytosis after intraperitoneal infection. Here, we identified an important in vivo function for SIGNR1 in S. pneumonia infection induced via its natural entrance route. Upon intranasal infection with S. pneumoniae, SIGNR1-deficient mice did not clear bacteria from lung and blood, and displayed severely enhanced inflammatory parameters compared to the wild-type mice. However, SIGNR1 is not expressed by alveolar macrophages, suggesting that another mechanism than a decrease in phagocytosis is responsible for this difference. Natural anti-phosphorylcholine IgM produced by marginal zone B cells is essential for protection against infection with S. pneumoniae. Strikingly, during infection, SIGNR1-deficient mice failed to produce a rapid anti-phosphorylcholine IgM response. Marginal zone macrophages have been suggested to capture antigens for presentation to marginal zone B cells. We demonstrate that marginal zone macrophages from SIGNR1-deficient mice in contrast to wild-type mice are not able to capture pneumococci from blood, suggesting that SIGNR1 on marginal zone macrophages captures S. pneumoniae for antigen presentation to and activation of marginal zone B cells, resulting in an anti-phosphorylcholine IgM response.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
CLEC4M	Human	Streptococcus pneumonia	severity	ISO	Cd209b (Mus musculus)		RGD
Cd209b	Mouse	Streptococcus pneumonia	severity	IMP			RGD
Clec4m	Rat	Streptococcus pneumonia	severity	ISO	Cd209b (Mus musculus)		RGD

Objects Annotated

Genes (Rattus norvegicus)

Clec4m (C-type lectin domain family 4 member M)

Genes (Mus musculus)

Cd209b (CD209b antigen)

Genes (Homo sapiens)

CLEC4M (C-type lectin domain family 4 member M)

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Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection.