RGD Reference Report - Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin-25-Mediated Protection from Amebic Colitis. - Rat Genome Database

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Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin-25-Mediated Protection from Amebic Colitis.

Authors: Noor, Zannatun  Watanabe, Koji  Abhyankar, Mayuresh M  Burgess, Stacey L  Buonomo, Erica L  Cowardin, Carrie A  Petri, William A 
Citation: Noor Z, etal., mBio. 2017 Feb 28;8(1). pii: mBio.02329-16. doi: 10.1128/mBio.02329-16.
RGD ID: 39128243
Pubmed: PMID:28246365   (View Abstract at PubMed)
PMCID: PMC5347349   (View Article at PubMed Central)
DOI: DOI:10.1128/mBio.02329-16   (Journal Full-text)

The parasite Entamoeba histolytica is a cause of diarrhea in infants in low-income countries. Previously, it was shown that tumor necrosis factor alpha (TNF-α) production was associated with increased risk of E. histolytica diarrhea in children. Interleukin-25 (IL-25) is a cytokine that is produced by intestinal epithelial cells that has a role in maintenance of gut barrier function and inhibition of TNF-α production. IL-25 expression was decreased in humans and in the mouse model of amebic colitis. Repletion of IL-25 blocked E. histolytica infection and barrier disruption in mice, increased gut eosinophils, and suppressed colonic TNF-α. Depletion of eosinophils with anti-Siglec-F antibody prevented IL-25-mediated protection. In contrast, depletion of TNF-α resulted in resistance to amebic infection. We concluded that IL-25 provides protection from amebiasis, which is dependent upon intestinal eosinophils and suppression of TNF-α.IMPORTANCE The intestinal epithelial barrier is important for protection from intestinal amebiasis. We discovered that the intestinal epithelial cytokine IL-25 was suppressed during amebic colitis in humans and that protection could be restored in the mouse model by IL-25 administration. IL-25 acted via eosinophils and suppressed TNF-α. This work illustrates a previously unrecognized pathway of innate mucosal immune response.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL25HumanAmoebic Dysentery due to Entamoeba Histolytica  IEP protein:decreased expression:intestineRGD 
Il25MouseAmoebic Dysentery due to Entamoeba Histolytica  IEP protein:decreased expression:intestineRGD 
Il25RatAmoebic Dysentery due to Entamoeba Histolytica  ISOIl25 (Mus musculus) and IL25 (Homo sapiens)protein:decreased expression:intestineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il25  (interleukin 25)

Genes (Mus musculus)
Il25  (interleukin 25)

Genes (Homo sapiens)
IL25  (interleukin 25)

Objects referenced in this article
Gene MYDGF myeloid derived growth factor Homo sapiens
Gene Mydgf myeloid derived growth factor Mus musculus
Gene Mydgf myeloid-derived growth factor Rattus norvegicus

Additional Information