RGD Reference Report - The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension. - Rat Genome Database

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The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension.

Authors: Watts, Stephanie W  Darios, Emma S  Mullick, Adam E  Garver, Hannah  Saunders, Thomas L  Hughes, Elizabeth D  Filipiak, Wanda E  Zeidler, Michael G  McMullen, Nichole  Sinal, Christopher J  Kumar, Ramya K  Ferland, David J  Fink, Gregory D 
Citation: Watts SW, etal., FASEB J. 2018 Jun 15:fj201800479. doi: 10.1096/fj.201800479.
RGD ID: 38596340
Pubmed: PMID:29906243   (View Abstract at PubMed)
PMCID: PMC6219827   (View Article at PubMed Central)
DOI: DOI:10.1096/fj.201800479   (Journal Full-text)

Measures of the adipokine chemerin are elevated in multiple cardiovascular diseases, including hypertension, but little mechanistic work has been done to implicate chemerin as being causative in such diseases. The chemerin knockout (KO) rat was created to test the hypothesis that removal of chemerin would reduce pressure in the normal and hypertensive state. Western analyses confirmed loss of chemerin in the plasma and tissues of the KO vs. wild-type (WT) rats. Chemerin concentration in plasma and tissues was lower in WT females than in WT males, as determined by Western analysis. Conscious male and female KO rats had modest differences in baseline measures vs. the WT that included systolic, diastolic, mean arterial and pulse pressures, and heart rate, all measured telemetrically. The mineralocorticoid deoxycorticosterone acetate (DOCA) and salt water, combined with uninephrectomy as a hypertensive stimulus, elevated mean and systolic blood pressures of the male KO higher than the male WT. By contrast, all pressures in the female KO were lower than their WT throughout DOCA-salt treatment. These results revealed an unexpected sex difference in chemerin expression and the ability of chemerin to modify blood pressure in response to a hypertensive challenge.-Watts, S. W., Darios, E. S., Mullick, A. E., Garver, H., Saunders, T. L., Hughes, E. D., Filipiak, W. E., Zeidler, M. G., McMullen, N., Sinal, C. J., Kumar, R. K., Ferland, D. J., Fink, G. D. The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rarres2Ratdecreased circulating aspartate transaminase level sexual_dimorphismIMP compared to male wild-typeRGD 
Rarres2Ratdecreased circulating aspartate transaminase level sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased circulating aspartate transaminase level sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased circulating aspartate transaminase level sexual_dimorphismIMP compared to male wild-typeRGD 
SD-Rarres2em1MsuRatdecreased circulating aspartate transaminase level sexual_dimorphismIMP compared to male wild-typeRGD 
Rarres2Ratdecreased heart rate sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
Rarres2Ratdecreased heart rate sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased heart rate sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased heart rate sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
SD-Rarres2em1MsuRatdecreased heart rate sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
Rarres2Ratdecreased mean systemic arterial blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to female wild-typeRGD 
Rarres2Ratdecreased mean systemic arterial blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased mean systemic arterial blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased mean systemic arterial blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to female wild-typeRGD 
SD-Rarres2em1MsuRatdecreased mean systemic arterial blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to female wild-typeRGD 
Rarres2Ratdecreased systemic arterial diastolic blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to female wild-typeRGD 
Rarres2Ratdecreased systemic arterial diastolic blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased systemic arterial diastolic blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased systemic arterial diastolic blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to female wild-typeRGD 
SD-Rarres2em1MsuRatdecreased systemic arterial diastolic blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to female wild-typeRGD 
Rarres2Ratdecreased systemic arterial systolic blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to female wild-typeRGD 
Rarres2Ratdecreased systemic arterial systolic blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased systemic arterial systolic blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatdecreased systemic arterial systolic blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to female wild-typeRGD 
SD-Rarres2em1MsuRatdecreased systemic arterial systolic blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to female wild-typeRGD 
Rarres2Ratincreased circulating serum albumin level sexual_dimorphism IAGP compared to male knockoutRGD 
Rarres2Ratincreased circulating serum albumin level sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatincreased circulating serum albumin level sexual_dimorphism IAGP compared to male knockoutRGD 
Rarres2em1MsuRatincreased circulating serum albumin level sexual_dimorphism IMP  RGD 
SD-Rarres2em1MsuRatincreased circulating serum albumin level sexual_dimorphism IAGP compared to male knockoutRGD 
Rarres2Ratincreased mean systemic arterial blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
Rarres2Ratincreased mean systemic arterial blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatincreased mean systemic arterial blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatincreased mean systemic arterial blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
SD-Rarres2em1MsuRatincreased mean systemic arterial blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
Rarres2Ratincreased pulse pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
Rarres2Ratincreased pulse pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatincreased pulse pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatincreased pulse pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
SD-Rarres2em1MsuRatincreased pulse pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
Rarres2Ratincreased systemic arterial diastolic blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatincreased systemic arterial diastolic blood pressure sexual_dimorphism IMP  RGD 
Rarres2Ratincreased systemic arterial systolic blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
Rarres2Ratincreased systemic arterial systolic blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatincreased systemic arterial systolic blood pressure sexual_dimorphism IMP  RGD 
Rarres2em1MsuRatincreased systemic arterial systolic blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
SD-Rarres2em1MsuRatincreased systemic arterial systolic blood pressure sexual_dimorphism IMPdeoxycorticosterone acetate and controlled sodium content dietcompared to male wild-typeRGD 
Rarres2Ratincreased vasoconstriction sexual_dimorphismIAGPchemerin-9compared to female knockoutRGD 
Rarres2Ratincreased vasoconstriction sexual_dimorphismIMPchemerin-9 RGD 
Rarres2Ratincreased vasoconstriction  IMP compared to wild-typeRGD 
Rarres2em1MsuRatincreased vasoconstriction  IMP compared to wild-typeRGD 
Rarres2em1MsuRatincreased vasoconstriction sexual_dimorphismIMPchemerin-9 RGD 
Rarres2em1MsuRatincreased vasoconstriction sexual_dimorphismIAGPchemerin-9compared to female knockoutRGD 
SD-Rarres2em1MsuRatincreased vasoconstriction inducedIMPchemerin-9compared to wild-typeRGD 
SD-Rarres2em1MsuRatincreased vasoconstriction sexual_dimorphismIAGPchemerin-9compared to female knockoutRGD 
Objects Annotated

Genes (Rattus norvegicus)
Rarres2  (retinoic acid receptor responder 2)
Rarres2em1Msu  (retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu)

Strains
SD-Rarres2em1Msu  (NA)


Additional Information