RGD Reference Report - Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines. - Rat Genome Database

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Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines.

Authors: Zheng, Zhenzhong  Yu, Yinghui  Potla, Ratnakar  Wu, Yujing  Wu, Hao 
Citation: Zheng Z, etal., Immunology. 2018 Feb;153(2):246-252. doi: 10.1111/imm.12837. Epub 2017 Oct 16.
RGD ID: 38549573
Pubmed: PMID:28892130   (View Abstract at PubMed)
PMCID: PMC5765378   (View Article at PubMed Central)
DOI: DOI:10.1111/imm.12837   (Journal Full-text)

Programmed death-1 (PD-1) plays an important role in protecting against inflammation and myocyte damage in T-cell-mediated myocarditis. To understand whether fibrinogen-like protein-2 (FGL2) can affect the role of the PD-1/PD-L1 pathway in experimental autoimmune myocarditis (EAM), we investigated cardiac function in EAM rats over-expressing FGL2. Over-expression of FGL2 significantly decreased PD-1 and deteriorated cardiac function in rats with autoimmune myocarditis. Histopathology revealed increased inflammatory cell infiltrate in EAM-FGL2 rats compared with the control groups (EAM, EAM-GFP and NC). Notably, transcription factor forkhead box P3 (Foxp3) and retinoic acid-related orphan receptor γt (RORγt) protein and mRNA levels were statistically (P < 0·05) increased in EAM rats. We also found that interferon-γ, interleukin-6, interleukin-17 and brain natriuretic peptide levels were profoundly increased in serum of FGL2 over-expressing EAM rats. Hence, FGL2 plays an important role in the pathogenesis of autoimmune myocarditis that also involves the PD-1/PD-L1 pathway. Our findings may provide novel therapeutic targets for the treatment of immune-induced heart injury.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Fgl2  (fibrinogen-like 2)
Foxp3  (forkhead box P3)
Rorc  (RAR-related orphan receptor C)

Genes (Mus musculus)
Fgl2  (fibrinogen-like protein 2)
Foxp3  (forkhead box P3)
Rorc  (RAR-related orphan receptor gamma)

Genes (Homo sapiens)
FGL2  (fibrinogen like 2)
FOXP3  (forkhead box P3)
RORC  (RAR related orphan receptor C)


Additional Information