RGD Reference Report - CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats.

Authors: Camara, Monika  Beyersdorf, Niklas  Fischer, Henrike J  Herold, Marco J  Ip, Chi Wang  van den Brandt, Jens  Toyka, Klaus V  Taurog, Joel D  Hünig, Thomas  Herrmann, Thomas  Reichardt, Holger M  Weishaupt, Andreas  Kerkau, Thomas 
Citation: Camara M, etal., J Neuroimmunol. 2013 Jul 15;260(1-2):17-27. doi: 10.1016/j.jneuroim.2013.04.014. Epub 2013 May 7.
RGD ID: 38508908
Pubmed: PMID:23664330   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2013.04.014   (Journal Full-text)

The role of CD8⁺ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8⁺ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD8⁺ T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-γ-producing effector cells. Our results indicate that CD8⁺ T cells interact with myelin-specific CD8⁺ T cells early in EAE enabling them to differentiate into pathogenic effector cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LEW/CrlRatExperimental Autoimmune Encephalomyelitis inducesIAGPcontrol IgG monoclonal antibody and Freund's complete adjuvant and myelin oligodendrocyte glycoproteincompared to mAb OX8 and 341 treatedRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

Strains
LEW.SD-CD8am1Trg  (NA)
LEW/Crl  (Lewis)


Additional Information