RGD Reference Report - Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.

Authors: Yang, Hong-Ju  Zhang, Hai-Ying  Bi, Guo-Hua  He, Yi  Gao, Jun-Tao  Xi, Zheng-Xiong 
Citation: Yang HJ, etal., Cell Rep. 2017 Jul 11;20(2):319-332. doi: 10.1016/j.celrep.2017.06.046.
RGD ID: 38501064
Pubmed: PMID:28700935   (View Abstract at PubMed)
PMCID: PMC5555082   (View Article at PubMed Central)
DOI: DOI:10.1016/j.celrep.2017.06.046   (Journal Full-text)

Cocaine users show reduced expression of the metabotropic glutamate receptor (mGluR2), but it is not clear whether this is a predisposing trait for addiction or a consequence of drug exposure. In this study, we found that a nonsense mutation at the mGluR2 gene decreased mGluR2 expression and altered the seeking and taking of cocaine. mGluR2 mutant rats show reduced sensitivity to cocaine reward, requiring more cocaine to reach satiation when it was freely available and ceasing their drug-seeking behavior sooner than controls when the response requirement was increased. mGluR2 mutant rats also show a lower propensity to relapse after a period of cocaine abstinence, an effect associated with reduced cocaine-induced dopamine and glutamate overflow in the nucleus accumbens. These findings suggest that mGluR2 polymorphisms or reduced availability of mGluR2 might be risk factors for the initial development of cocaine use but could actually protect against addiction by reducing sensitivity to cocaine reward.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GRM2HumanCocaine-Related Disorders  ISOGrm2 (Rattus norvegicus)knockout compared to wild typeRGD 
Grm2RatCocaine-Related Disorders  IMP knockout compared to wild typeRGD 
Grm2MouseCocaine-Related Disorders  ISOGrm2 (Rattus norvegicus)knockout compared to wild typeRGD 
Grm2em1RatCocaine-Related Disorders  IMP KO compared to wild-type ratsRGD 
WI-Grm2em1RatCocaine-Related Disorders  IMP KO compared to wild-type ratsRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Grm2Ratbehavioral response to nicotine  IMP  RGD 
Grm2Ratregulation of glutamate secretion  IMP  RGD 
Grm2Ratregulation of response to drug  IMP  RGD 
Grm2Ratresponse to cocaine  IMP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Grm2Ratabnormal cocaine self-administration  IMP KO compared to wild-type ratsRGD 
Grm2em1Ratabnormal cocaine self-administration  IMP KO compared to wild-type ratsRGD 
WI-Grm2em1Ratabnormal cocaine self-administration  IMP KO compared to wild-type ratsRGD 
Grm2Ratabnormal cue-induced reinstatement of an extinguished operant behavior for a cocaine reinforcer  IMP knockout compared to wild typeRGD 
Grm2em1Ratabnormal cue-induced reinstatement of an extinguished operant behavior for a cocaine reinforcer  IMP KO compared to wild-type ratsRGD 
WI-Grm2em1Ratabnormal cue-induced reinstatement of an extinguished operant behavior for a cocaine reinforcer  IMP KO compared to wild-type ratsRGD 
Grm2Ratabnormal extinction of cocaine self-administration  IMP knockout compared to wild typeRGD 
Grm2em1Ratabnormal extinction of cocaine self-administration  IMP KO compared to wild-type ratsRGD 
WI-Grm2em1Ratabnormal extinction of cocaine self-administration  IMP KO compared to wild-type ratsRGD 
Grm2Ratabnormal neurotransmitter secretion  IMP knockout compared to wild typeRGD 
Grm2em1Ratabnormal neurotransmitter secretion  IMP KO compared to wild-type ratsRGD 
WI-Grm2em1Ratabnormal neurotransmitter secretion  IMP KO compared to wild-type ratsRGD 
Grm2Ratabnormal response to electrical stimuli  IMP knockout compared to wild typeRGD 
Grm2em1Ratabnormal response to electrical stimuli  IMP KO compared to wild-type ratsRGD 
WI-Grm2em1Ratabnormal response to electrical stimuli  IMP KO compared to wild-type ratsRGD 
Grm2Rataddiction  IMP knockout compared to wild typeRGD 
Grm2em1Rataddiction  IMP KO compared to wild-type ratsRGD 
WI-Grm2em1Rataddiction  IMP KO compared to wild-type ratsRGD 
Grm2Ratenhanced behavioral response to cocaine  IMP knockout compared to wild typeRGD 
Grm2em1Ratenhanced behavioral response to cocaine  IMP KO compared to wild-type ratsRGD 
WI-Grm2em1Ratenhanced behavioral response to cocaine  IMP KO compared to wild-type ratsRGD 
Grm2Ratenhanced behavioral response to morphine  IMP knockout compared to wild typeRGD 
Grm2Ratenhanced behavioral response to nicotine  IMP knockout compared to wild typeRGD 
Grm2em1Ratenhanced behavioral response to nicotine  IMP KO compared to wild-type ratsRGD 
WI-Grm2em1Ratenhanced behavioral response to nicotine  IMP KO compared to wild-type ratsRGD 
Objects Annotated

Genes (Rattus norvegicus)
Grm2  (glutamate metabotropic receptor 2)
Grm2em1  (glutamate metabotropic receptor 2; endonuclease induced mutant 1)

Genes (Mus musculus)
Grm2  (glutamate receptor, metabotropic 2)

Genes (Homo sapiens)
GRM2  (glutamate metabotropic receptor 2)

Strains
WI-Grm2em1  (NA)


Additional Information