RGD Reference Report - Overexpression of FGFR3 in HPV-positive Tonsillar and Base of Tongue Cancer Is Correlated to Outcome. - Rat Genome Database

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Overexpression of FGFR3 in HPV-positive Tonsillar and Base of Tongue Cancer Is Correlated to Outcome.

Authors: Bersani, Cinzia  Haeggblom, Linnea  Ursu, Ramona G  Giusca, Simona E  Marklund, Linda  Ramqvist, Torbjörn  Näsman, Anders  Dalianis, Tina 
Citation: Bersani C, etal., Anticancer Res. 2018 Aug;38(8):4683-4690. doi: 10.21873/anticanres.12774.
RGD ID: 36947883
Pubmed: PMID:30061236   (View Abstract at PubMed)
DOI: DOI:10.21873/anticanres.12774   (Journal Full-text)


BACKGROUND/AIM: Human papillomavirus-positive (HPV+) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) have better outcome than corresponding HPV- cancers. To better individualize treatment, additional predictive markers are needed. Previously, we have shown that mutated fibroblast growth factor receptor 3 protein (FGFR3) was correlated to poorer prognosis and here FGFR3 expression was further analyzed.
PATIENTS AND METHODS: One-hundred-fifteen HPV+TSCC/ BOTSCC biopsies were analyzed for FGFR3 by immunohistochemistry (IHC), and 109/115 were analyzed for FGFR3 mutations by Ion Proton sequencing, or by Competitive Allele-Specific Taqman PCR (CAST-PCR). Disease-free survival (DFS) was then calculated according to FGFR3 IHC expression.
RESULTS: CAST-PCR was useful for detecting the three most common FGFR3 mutations. Focusing especially on the 98/115 patients with HPV+TSCC/BOTSCC and wild-type FGFR3, high FGFR3 expression correlated to significantly better 3-year DFS, p=0.043.
CONCLUSION: In patients with HPV+TSCC/BOTSCC and wild-type FGFR3, overexpression of FGFR3 was correlated with better DFS.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FGFR3Humantongue cancer severityIEP associated with human papillomavirus;protein:decreased expression:tumor cellsRGD 
Fgfr3Rattongue cancer severityISOFGFR3 (Homo sapiens)associated with human papillomavirus;protein:decreased expression:tumor cellsRGD 
Fgfr3Mousetongue cancer severityISOFGFR3 (Homo sapiens)associated with human papillomavirus;protein:decreased expression:tumor cellsRGD 
FGFR3Humantonsil squamous cell carcinoma severityIEP associated with human papillomavirus;protein:decreased expression:tumor cells (human)RGD 
Fgfr3Rattonsil squamous cell carcinoma severityISOFGFR3 (Homo sapiens)associated with human papillomavirus;protein:decreased expression:tumor cells (human)RGD 
Fgfr3Mousetonsil squamous cell carcinoma severityISOFGFR3 (Homo sapiens)associated with human papillomavirus;protein:decreased expression:tumor cells (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fgfr3  (fibroblast growth factor receptor 3)

Genes (Mus musculus)
Fgfr3  (fibroblast growth factor receptor 3)

Genes (Homo sapiens)
FGFR3  (fibroblast growth factor receptor 3)


Additional Information