RGD Reference Report - Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice.

Authors: Shi, Guangjiang  Zhang, Zixuan  Ma, Shuqian  Li, Yan  Du, Shijia  Chu, Ya  Li, Yuan  Tang, Xinying  Yang, Yong  Chen, Zhen  Wang, Zhuo  Wu, Hongxi 
Citation: Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
RGD ID: 329902072
Pubmed: PMID:34400126   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bcp.2021.114728   (Journal Full-text)

Hepatic ischemia/reperfusion (I/R) injury is an inevitable complication of hepatic surgery occasioned by liver transplantation and resection. The progression from liver ischemia to reperfusion injury is accompanied by abnormal metabolism, Kupffer cell activation, neutrophil recruitment and the release of cytokines. Activation of several interferon regulatory factors (IRFs) has been reported to either enhance or restrict I/R progression, but the role of IRF8 in the regulation of I/R injury progression is still unknown. In this study, we explore the IRF8 function in the I/R-mediated liver injury using overexpressed hepatic IRF8 and knockout mice. According to our results, IRF8 knockout mice had significantly lower inflammatory cells infiltration, inflammatory cytokines release and serum aspartate aminotransferase/alanine aminotransferase levels that improved the necrotic injury after I/R, unlike the control mice. Conversely, the overexpression of IRF8 in WT mice markedly aggravated the liver structure damage and its abnormal function. We further showed that IRF8-mediated inflammatory cells infiltration were partly dependent on early autophagy and NF-κΒ signal pathway during I/R. AAV8-IRF8-I/R mice pretreated with autophagy inhibitor hydroxychloroquine and NF-κΒ signal pathway inhibitor secukinumab could drastically reverse the IRF8-mediated increase of neutrophil infiltration and chemokine release at different degrees. This work uncovered a critical role of IRF8 in the modulation of the hepatic microenvironment and as a potential target in the initial treatment of I/R injury.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ATG13HumanLiver Reperfusion Injury amelioratesISOAtg13 (Mus musculus) RGD 
ATG16L1HumanLiver Reperfusion Injury amelioratesISOAtg16l1 (Mus musculus) RGD 
ATG4DHumanLiver Reperfusion Injury amelioratesISOAtg4d (Mus musculus) RGD 
ATG7HumanLiver Reperfusion Injury amelioratesISOAtg7 (Mus musculus) RGD 
Atg13RatLiver Reperfusion Injury amelioratesISOAtg13 (Mus musculus) RGD 
Atg13MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Atg16l1RatLiver Reperfusion Injury amelioratesISOAtg16l1 (Mus musculus) RGD 
Atg16l1MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Atg4dRatLiver Reperfusion Injury amelioratesISOAtg4d (Mus musculus) RGD 
Atg4dMouseLiver Reperfusion Injury amelioratesIEP  RGD 
Atg7RatLiver Reperfusion Injury amelioratesISOAtg7 (Mus musculus) RGD 
Atg7MouseLiver Reperfusion Injury amelioratesIEP  RGD 
BECN1HumanLiver Reperfusion Injury amelioratesISOBecn1 (Mus musculus) RGD 
Becn1RatLiver Reperfusion Injury amelioratesISOBecn1 (Mus musculus) RGD 
Becn1MouseLiver Reperfusion Injury amelioratesIEP  RGD 
CCL2HumanLiver Reperfusion Injury amelioratesISOCcl2 (Mus musculus) RGD 
CCL7HumanLiver Reperfusion Injury amelioratesISOCcl7 (Mus musculus) RGD 
CCR1HumanLiver Reperfusion Injury amelioratesISOCcr1 (Mus musculus) RGD 
CST3HumanLiver Reperfusion Injury amelioratesISOCst3 (Mus musculus) RGD 
CXCL1HumanLiver Reperfusion Injury amelioratesISOCxcl1 (Mus musculus) RGD 
CXCL10HumanLiver Reperfusion Injury amelioratesISOCxcl10 (Mus musculus) RGD 
CXCL2HumanLiver Reperfusion Injury amelioratesISOCxcl2 (Mus musculus) RGD 
CXCL6HumanLiver Reperfusion Injury amelioratesISOCxcl5 (Mus musculus) RGD 
CXCL9HumanLiver Reperfusion Injury amelioratesISOCxcl9 (Mus musculus) RGD 
Ccl2RatLiver Reperfusion Injury amelioratesISOCcl2 (Mus musculus) RGD 
Ccl2MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Ccl7RatLiver Reperfusion Injury amelioratesISOCcl7 (Mus musculus) RGD 
Ccl7MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Ccr1RatLiver Reperfusion Injury amelioratesISOCcr1 (Mus musculus) RGD 
Ccr1MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Cst3RatLiver Reperfusion Injury amelioratesISOCst3 (Mus musculus) RGD 
Cst3MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Cxcl1RatLiver Reperfusion Injury amelioratesISOCxcl1 (Mus musculus) RGD 
Cxcl1MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Cxcl10RatLiver Reperfusion Injury amelioratesISOCxcl10 (Mus musculus) RGD 
Cxcl10MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Cxcl2RatLiver Reperfusion Injury amelioratesISOCxcl2 (Mus musculus) RGD 
Cxcl2MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Cxcl5MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Cxcl6RatLiver Reperfusion Injury amelioratesISOCxcl5 (Mus musculus) RGD 
Cxcl9RatLiver Reperfusion Injury amelioratesISOCxcl9 (Mus musculus) RGD 
Cxcl9MouseLiver Reperfusion Injury amelioratesIEP  RGD 
IL1BHumanLiver Reperfusion Injury amelioratesISOIl1b (Mus musculus) RGD 
IL6HumanLiver Reperfusion Injury amelioratesISOIl6 (Mus musculus) RGD 
IRF8HumanLiver Reperfusion Injury amelioratesISOIrf8 (Mus musculus) RGD 
Il1bRatLiver Reperfusion Injury amelioratesISOIl1b (Mus musculus) RGD 
Il1bMouseLiver Reperfusion Injury amelioratesIEP  RGD 
Il6RatLiver Reperfusion Injury amelioratesISOIl6 (Mus musculus) RGD 
Il6MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Irf8RatLiver Reperfusion Injury amelioratesISOIrf8 (Mus musculus) RGD 
Irf8MouseLiver Reperfusion Injury amelioratesIMP  RGD 
LAMP2HumanLiver Reperfusion Injury amelioratesISOLamp2 (Mus musculus) RGD 
Lamp2RatLiver Reperfusion Injury amelioratesISOLamp2 (Mus musculus) RGD 
Lamp2MouseLiver Reperfusion Injury amelioratesIEP  RGD 
MAP1LC3BHumanLiver Reperfusion Injury amelioratesISOMap1lc3b (Mus musculus) RGD 
Map1lc3bRatLiver Reperfusion Injury amelioratesISOMap1lc3b (Mus musculus) RGD 
Map1lc3bMouseLiver Reperfusion Injury amelioratesIEP  RGD 
RAB10HumanLiver Reperfusion Injury amelioratesISORab10 (Mus musculus) RGD 
RAB8BHumanLiver Reperfusion Injury amelioratesISORab8b (Mus musculus) RGD 
Rab10RatLiver Reperfusion Injury amelioratesISORab10 (Mus musculus) RGD 
Rab10MouseLiver Reperfusion Injury amelioratesIEP  RGD 
Rab8bRatLiver Reperfusion Injury amelioratesISORab8b (Mus musculus) RGD 
Rab8bMouseLiver Reperfusion Injury amelioratesIEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atg13  (autophagy related 13)
Atg16l1  (autophagy related 16-like 1)
Atg4d  (autophagy related 4D, cysteine peptidase)
Atg7  (autophagy related 7)
Becn1  (beclin 1)
Ccl2  (C-C motif chemokine ligand 2)
Ccl7  (C-C motif chemokine ligand 7)
Ccr1  (C-C motif chemokine receptor 1)
Cst3  (cystatin C)
Cxcl1  (C-X-C motif chemokine ligand 1)
Cxcl10  (C-X-C motif chemokine ligand 10)
Cxcl2  (C-X-C motif chemokine ligand 2)
Cxcl6  (C-X-C motif chemokine ligand 6)
Cxcl9  (C-X-C motif chemokine ligand 9)
Il1b  (interleukin 1 beta)
Il6  (interleukin 6)
Irf8  (interferon regulatory factor 8)
Lamp2  (lysosomal-associated membrane protein 2)
Map1lc3b  (microtubule-associated protein 1 light chain 3 beta)
Rab10  (RAB10, member RAS oncogene family)
Rab8b  (RAB8B, member RAS oncogene family)

Genes (Mus musculus)
Atg13  (autophagy related 13)
Atg16l1  (autophagy related 16 like 1)
Atg4d  (autophagy related 4D, cysteine peptidase)
Atg7  (autophagy related 7)
Becn1  (beclin 1, autophagy related)
Ccl2  (C-C motif chemokine ligand 2)
Ccl7  (C-C motif chemokine ligand 7)
Ccr1  (C-C motif chemokine receptor 1)
Cst3  (cystatin C)
Cxcl1  (C-X-C motif chemokine ligand 1)
Cxcl10  (C-X-C motif chemokine ligand 10)
Cxcl2  (C-X-C motif chemokine ligand 2)
Cxcl5  (C-X-C motif chemokine ligand 5)
Cxcl9  (C-X-C motif chemokine ligand 9)
Il1b  (interleukin 1 beta)
Il6  (interleukin 6)
Irf8  (interferon regulatory factor 8)
Lamp2  (lysosomal-associated membrane protein 2)
Map1lc3b  (microtubule-associated protein 1 light chain 3 beta)
Rab10  (RAB10, member RAS oncogene family)
Rab8b  (RAB8B, member RAS oncogene family)

Genes (Homo sapiens)
ATG13  (autophagy related 13)
ATG16L1  (autophagy related 16 like 1)
ATG4D  (autophagy related 4D cysteine peptidase)
ATG7  (autophagy related 7)
BECN1  (beclin 1)
CCL2  (C-C motif chemokine ligand 2)
CCL7  (C-C motif chemokine ligand 7)
CCR1  (C-C motif chemokine receptor 1)
CST3  (cystatin C)
CXCL1  (C-X-C motif chemokine ligand 1)
CXCL10  (C-X-C motif chemokine ligand 10)
CXCL2  (C-X-C motif chemokine ligand 2)
CXCL6  (C-X-C motif chemokine ligand 6)
CXCL9  (C-X-C motif chemokine ligand 9)
IL1B  (interleukin 1 beta)
IL6  (interleukin 6)
IRF8  (interferon regulatory factor 8)
LAMP2  (lysosomal associated membrane protein 2)
MAP1LC3B  (microtubule associated protein 1 light chain 3 beta)
RAB10  (RAB10, member RAS oncogene family)
RAB8B  (RAB8B, member RAS oncogene family)


Additional Information