RGD Reference Report - Inhibition of human neutrophils NEP activity, CD11b/CD18 expression and elastase release by 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde, oleacein. - Rat Genome Database

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Inhibition of human neutrophils NEP activity, CD11b/CD18 expression and elastase release by 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde, oleacein.

Authors: Czerwińska, Monika E  Kiss, Anna K  Naruszewicz, Marek 
Citation: Czerwińska ME, etal., Food Chem. 2014 Jun 15;153:1-8. doi: 10.1016/j.foodchem.2013.12.019. Epub 2013 Dec 11.
RGD ID: 329853765
Pubmed: PMID:24491692   (View Abstract at PubMed)
DOI: DOI:10.1016/j.foodchem.2013.12.019   (Journal Full-text)

Polyphenols, such as oleacein (3,4-DHPEA-EDA; 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde), are believed to play a role in the prevention of cardiovascular diseases. Due to an increase of neutrophil mediators in acute myocardial infarction the aim of this study was to establish the effect of oleacein on neutral endopeptidase (NEP) activity and other functions of human neutrophils, such as elastase, MMP-9 and IL-8 production. The effect on CD62L and CD11b/CD18 expression on neutrophils was also determined. Oleacein with a concentration of 100 μM inhibited NEP activity, elastase, MMP-9 and IL-8 release from neutrophils by 77.7 ± 2.7%, 21.3 ± 7.8%, 22.7 ± 4.2% and 25.2 ± 5.6%, respectively. Oleacein with a concentration of 50 μM suppressed CD11b/CD18 expression by 63.6 ± 3.1% and to a lesser extent, increased CD62L expression by 27.3 ± 8.3% on the surface of neutrophils, in comparison with stimulated cells. Oleacein by inhibiting NEP activity, adhesion molecules expression and elastase release might play a role in the protective effects of olive oil against endothelial injuries.



Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ITGAMHumanlipopolysaccharide increases expression EXP Lipopolysaccharide increases expression of ITGAM protein on neutrophilsRGD 
ItgamRatlipopolysaccharide increases expression ISOITGAM (Homo sapiens)Lipopolysaccharide increases expression of ITGAM protein on neutrophilsRGD 
ItgamMouselipopolysaccharide increases expression ISOITGAM (Homo sapiens)Lipopolysaccharide increases expression of ITGAM protein on neutrophilsRGD 
ITGAMHumanOleacein multiple interactionsEXP Oleacein inhibits the reaction [lipopolysaccharide increases expression of ITGAM protein on neutrophils]RGD 
ItgamRatOleacein multiple interactionsISOITGAM (Homo sapiens)Oleacein inhibits the reaction [lipopolysaccharide increases expression of ITGAM protein on neutrophils]RGD 
ItgamMouseOleacein multiple interactionsISOITGAM (Homo sapiens)Oleacein inhibits the reaction [lipopolysaccharide increases expression of ITGAM protein on neutrophils]RGD 

Objects Annotated

Genes (Rattus norvegicus)
Itgam  (integrin subunit alpha M)

Genes (Mus musculus)
Itgam  (integrin alpha M)

Genes (Homo sapiens)
ITGAM  (integrin subunit alpha M)


Additional Information