RGD Reference Report - Elevated serum retinol-binding protein 4 levels are correlated with blood pressure in prehypertensive Chinese. - Rat Genome Database

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Elevated serum retinol-binding protein 4 levels are correlated with blood pressure in prehypertensive Chinese.

Authors: Zhang, J-X  Zhu, G-P  Zhang, B-L  Cheng, Y-Y 
Citation: Zhang JX, etal., J Hum Hypertens. 2017 Oct;31(10):611-615. doi: 10.1038/jhh.2017.44. Epub 2017 Jun 22.
RGD ID: 329845595
Pubmed: PMID:28639612   (View Abstract at PubMed)
DOI: DOI:10.1038/jhh.2017.44   (Journal Full-text)

Retinol-binding protein 4 (RBP4) has been reported involving in the occurrence and development of hypertension. However, to date, few data are available on the correlation between serum RBP4 level and blood pressure (BP) in prehypertension. Therefore, this association was investigated in prehypertensive Chinese. Overall, 160 subjects with prehypertension (Pre-HT group) and 160 subjects with normal BP (NBP group) were recruited in this study. The subjects were divided into the following four subgroups according to body mass index (BMI): obese Pre-HT subgroup; non-obese Pre-HT subgroup; obese NBP subgroup; and non-obese NBP subgroup (n=80 in each). Anthropometric parameters, systolic BP (SBP), diastolic BP (DBP) and several biochemical parameters were measured. Fasting insulin was evaluated by radioimmunoassay. Serum RBP4 level was measured by enzyme-linked immunosorbent assay. The Pre-HT group had higher levels of serum RBP4 level than did the NBP group (P<0.001). Moreover, higher RBP4 levels were identified in the obese Pre-HT subgroup relative to the non-obese Pre-HT subgroup (P=0.005). However, no difference in RBP4 level was identified between the obese and the non-obese NBP subgroups (P=0.317). RBP4 level was positively correlated with BMI (r=0.226, P=0.001), SBP (r=0.468, P<0.001) and DBP (r=0.358, P<0.001) after adjustment for age, sex, smoking status and alcohol consumption. The results of the multiple regression analyses demonstrated that RBP4 level was independently associated with SBP (β=0.427, P<0.001) and DBP (β=0.338, P<0.001). In conclusion, serum RBP4 level was significantly higher and closely associated with BP in prehypertensive Chinese.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RBP4HumanPrehypertension  IEP associated with obesity and protein:increased expression:blood serum (human)RGD 
Rbp4RatPrehypertension  ISORBP4 (Homo sapiens)associated with obesity and protein:increased expression:blood serum (human)RGD 
Rbp4MousePrehypertension  ISORBP4 (Homo sapiens)associated with obesity and protein:increased expression:blood serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rbp4  (retinol binding protein 4)

Genes (Mus musculus)
Rbp4  (retinol binding protein 4, plasma)

Genes (Homo sapiens)
RBP4  (retinol binding protein 4)


Additional Information