RGD Reference Report - Catalpol attenuates cardiomyocyte apoptosis in diabetic cardiomyopathy via Neat1/miR-140-5p/HDAC4 axis. - Rat Genome Database

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Catalpol attenuates cardiomyocyte apoptosis in diabetic cardiomyopathy via Neat1/miR-140-5p/HDAC4 axis.

Authors: Zou, GuoLiang  Zhong, WeiLi  Wu, Fan  Wang, XiaoXue  Liu, Li 
Citation: Zou G, etal., Biochimie. 2019 Oct;165:90-99. doi: 10.1016/j.biochi.2019.05.005. Epub 2019 May 9.
RGD ID: 329347833
Pubmed: PMID:31078585   (View Abstract at PubMed)
DOI: DOI:10.1016/j.biochi.2019.05.005   (Journal Full-text)

The cardioprotection of catalpol and its mechanism in diabetic cardiomyopathy (DCM) remains unclear. Here, mouse cardiomyocytes were treated with high glucose (HG) to establish a model of cellular injury induced by HG. In vitro experiments were carried out and confirmed that Catalpol attenuated HG-induced long noncoding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (Neat1) expression in mouse cardiomyocytes. Mechanistically, luciferase reporter analysis indicated that Neat1 could decrease the transcription of miR-140-5p to positively regulate histone deacetylase 4 (HDAC4) expression. Notably, overexpression of miR-140-5p or silencing of HDAC4 rescued Neat1-induced cardiomyocyte apoptosis. DCM was induced in male C57BL/6 mice by intraperitoneal injection with streptozotocin (STZ) combined with a high-fat/high-sugar diet. Further in vivo experiments identified that Catalpol alleviated myocardial damage by regulating Neat1/miR-140-5p/HDAC4 axis in DCM mice. Thus, our results demonstrated that Catalpol could exert cardioprotective effect against DCM via Neat1/miR-140-5p/HDAC4 pathway.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR140HumanDiabetic Cardiomyopathies amelioratesISOMir140 (Mus musculus) RGD 
Mir140MouseDiabetic Cardiomyopathies amelioratesIEP  RGD 
Mir140RatDiabetic Cardiomyopathies amelioratesISOMir140 (Mus musculus) RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR140Humancatalpol multiple interactionsISOMir140 (Mus musculus)catalpol inhibits the reaction [Diabetic Cardiomyopathies decrease the expression of Mir140 RNA in myocardium] RGD 
Mir140Mousecatalpol multiple interactionsEXP catalpol inhibits the reaction [Diabetic Cardiomyopathies decrease the expression of Mir140 RNA in myocardium] RGD 
Mir140Ratcatalpol multiple interactionsISOMir140 (Mus musculus)catalpol inhibits the reaction [Diabetic Cardiomyopathies decrease the expression of Mir140 RNA in myocardium] RGD 
MIR140HumanD-glucose multiple interactionsISOMir140 (Mus musculus)catalpol inhibits the reaction [D-glucose decreases expression of Mir140 in cardiomyocytes] RGD 
Mir140MouseD-glucose multiple interactionsEXP catalpol inhibits the reaction [D-glucose decreases expression of Mir140 in cardiomyocytes] RGD 
Mir140RatD-glucose multiple interactionsISOMir140 (Mus musculus)catalpol inhibits the reaction [D-glucose decreases expression of Mir140 in cardiomyocytes] RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir140  (microRNA 140)

Genes (Mus musculus)
Mir140  (microRNA 140)

Genes (Homo sapiens)
MIR140  (microRNA 140)


Additional Information