RGD Reference Report - PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists. - Rat Genome Database

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PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists.

Authors: Iwata, Miki  Maturana, Andrés  Hoshijima, Masahiko  Tatematsu, Kenji  Okajima, Toshihide  Vandenheede, Jackie R  Van Lint, Johan  Tanizawa, Katsuyuki  Kuroda, Shun'ichi 
Citation: Iwata M, etal., Biochem Biophys Res Commun. 2005 Feb 25;327(4):1105-13. doi: 10.1016/j.bbrc.2004.12.128.
RGD ID: 288084581
Pubmed: PMID:15652511   (View Abstract at PubMed)
PMCID: PMC3224855   (View Article at PubMed Central)
DOI: DOI:10.1016/j.bbrc.2004.12.128   (Journal Full-text)

Cardiac hypertrophy is triggered in response to mechanical stress and various neurohumoral factors, such as G-protein coupling receptor (GPCR) and gp130 cytokine receptor agonists. Recent studies have suggested cardiac Z-disc plays a pivotal role to regulate these cellular responses. Here, we demonstrate stimulations with GPCR agonists (norepinephrine, angiotensin II, and endothelin 1) and phorbol ester activated and translocated protein kinase D1 (PKD1) to the Z-discs in neonatal rat cardiomyocytes in a protein kinase C (PKC)-dependent manner, whereas gp130 agonist did not. Especially, upon the alpha-adrenergic receptor agonist stimulations, following the PKCepsilon-PKD1 complex formation, PKCepsilon-dependent activation of PKD1 was essential to induce hypertrophic responses. Constitutively active mutant of either PKD1 or PKCepsilon also induced cardiac hypertrophy ex vivo. Taken together, the PKCepsilon-PKD1 complex at Z-discs could play a pivotal role in the cardiac hypertrophy induced by GPCR agonists, at least alpha-adrenergic receptor agonist.



Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PRKD1Humanangiotensin II affects localizationISOPrkd1 (Rattus norvegicus)Angiotensin II affects localization of Prkd1 protein in cardiomyocytesRGD 
Prkd1Ratangiotensin II affects localizationEXP Angiotensin II affects localization of Prkd1 protein in cardiomyocytesRGD 
Prkd1Mouseangiotensin II affects localizationISOPrkd1 (Rattus norvegicus)Angiotensin II affects localization of Prkd1 protein in cardiomyocytesRGD 
PRKD1HumanEndothelin-1 affects localizationISOPrkd1 (Rattus norvegicus)Endothelin-1 affects localization of Prkd1 protein in cardiomyocytesRGD 
Prkd1RatEndothelin-1 affects localizationEXP Endothelin-1 affects localization of Prkd1 protein in cardiomyocytesRGD 
Prkd1MouseEndothelin-1 affects localizationISOPrkd1 (Rattus norvegicus)Endothelin-1 affects localization of Prkd1 protein in cardiomyocytesRGD 
PRKD1Humannoradrenaline affects localizationISOPrkd1 (Rattus norvegicus)[Norepinephrine cotreated with propranolol] affects localization of Prkd1 protein in cardiomyocytesRGD 
Prkd1Ratnoradrenaline affects localizationEXP [Norepinephrine cotreated with propranolol] affects localization of Prkd1 protein in cardiomyocytesRGD 
Prkd1Mousenoradrenaline affects localizationISOPrkd1 (Rattus norvegicus)[Norepinephrine cotreated with propranolol] affects localization of Prkd1 protein in cardiomyocytesRGD 
PRKD1Humanphorbol 13-acetate 12-myristate affects localizationISOPrkd1 (Rattus norvegicus)TPA affects localization of Prkd1 protein in cardiomyocytesRGD 
Prkd1Ratphorbol 13-acetate 12-myristate affects localizationEXP TPA affects localization of Prkd1 protein in cardiomyocytesRGD 
Prkd1Mousephorbol 13-acetate 12-myristate affects localizationISOPrkd1 (Rattus norvegicus)TPA affects localization of Prkd1 protein in cardiomyocytesRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Prkd1Ratcellular response to angiotensin  IDA  RGD 
Prkd1Ratcellular response to endothelin  IDA Endothelin-1RGD 
Prkd1Ratcellular response to norepinephrine stimulus  IDA  RGD 
Prkd1Ratcellular response to phorbol 13-acetate 12-myristate  IDA TPARGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Prkd1Ratmembrane  IDA  RGD 
Prkd1Ratperinuclear region of cytoplasm  IDA  RGD 
Prkd1RatZ disc  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Prkd1Ratprotein kinase C binding  IPIPrkce (Rattus norvegicus) RGD 
PrkceRatprotein serine/threonine kinase binding  IPIPrkd1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Prkce  (protein kinase C, epsilon)
Prkd1  (protein kinase D1)

Genes (Mus musculus)
Prkd1  (protein kinase D1)

Genes (Homo sapiens)
PRKD1  (protein kinase D1)


Additional Information