RGD Reference Report - Sulfonamide inhibition of rat hepatic uroporphyrinogen I synthetase activity and the biosynthesis of heme. - Rat Genome Database

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Sulfonamide inhibition of rat hepatic uroporphyrinogen I synthetase activity and the biosynthesis of heme.

Authors: Peters, P G  Sharma, M L  Hardwicke, D M  Piper, W N 
Citation: Peters PG, etal., Arch Biochem Biophys. 1980 Apr 15;201(1):88-94. doi: 10.1016/0003-9861(80)90490-7.
RGD ID: 26923963
Pubmed: PMID:6893114   (View Abstract at PubMed)
DOI: DOI:10.1016/0003-9861(80)90490-7   (Journal Full-text)

Abstract for this paper unavailable



Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HMBSHumansulfacetamide decreases activityISORGD:2801Sulfacetamide decreases activity of purified Hmbs proteinRGD 
HmbsRatsulfacetamide decreases activityEXP Sulfacetamide decreases activity of purified Hmbs proteinRGD 
HmbsMousesulfacetamide decreases activityISORGD:2801Sulfacetamide decreases activity of purified Hmbs proteinRGD 
HMBSHumansulfadiazine decreases activityISORGD:2801Sulfadiazine decreases activity of purified Hmbs proteinRGD 
HmbsRatsulfadiazine decreases activityEXP Sulfadiazine decreases activity of purified Hmbs proteinRGD 
HmbsMousesulfadiazine decreases activityISORGD:2801Sulfadiazine decreases activity of purified Hmbs proteinRGD 
HMBSHumansulfamerazine decreases activityISORGD:2801Sulfamerazine decreases activity of purified Hmbs proteinRGD 
HmbsRatsulfamerazine decreases activityEXP Sulfamerazine decreases activity of purified Hmbs proteinRGD 
HmbsMousesulfamerazine decreases activityISORGD:2801Sulfamerazine decreases activity of purified Hmbs proteinRGD 
HMBSHumansulfamoxole decreases activityISORGD:2801Sulfamoxole decreases activity of purified Hmbs proteinRGD 
HmbsRatsulfamoxole decreases activityEXP Sulfamoxole decreases activity of purified Hmbs proteinRGD 
HmbsMousesulfamoxole decreases activityISORGD:2801Sulfamoxole decreases activity of purified Hmbs proteinRGD 
HMBSHumansulfanilamide decreases activityISORGD:2801Sulfanilamide decreases activity of purified Hmbs proteinRGD 
HmbsRatsulfanilamide decreases activityEXP Sulfanilamide decreases activity of purified Hmbs proteinRGD 
HmbsMousesulfanilamide decreases activityISORGD:2801Sulfanilamide decreases activity of purified Hmbs proteinRGD 
HMBSHumansulfapyridine decreases activityISORGD:2801Sulfapyridine decreases activity of purified Hmbs proteinRGD 
HmbsRatsulfapyridine decreases activityEXP Sulfapyridine decreases activity of purified Hmbs proteinRGD 
HmbsMousesulfapyridine decreases activityISORGD:2801Sulfapyridine decreases activity of purified Hmbs proteinRGD 
HMBSHumansulfisomidine decreases activityISORGD:2801Sulfisomidine decreases activity of purified Hmbs proteinRGD 
HmbsRatsulfisomidine decreases activityEXP Sulfisomidine decreases activity of purified Hmbs proteinRGD 
HmbsMousesulfisomidine decreases activityISORGD:2801Sulfisomidine decreases activity of purified Hmbs proteinRGD 
HMBSHumansulfisoxazole decreases activityISORGD:2801Sulfisoxazole decreases activity of purified Hmbs proteinRGD 
HmbsRatsulfisoxazole decreases activityEXP Sulfisoxazole decreases activity of purified Hmbs proteinRGD 
HmbsMousesulfisoxazole decreases activityISORGD:2801Sulfisoxazole decreases activity of purified Hmbs proteinRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HmbsRatporphyrin-containing compound biosynthetic process  IDA Uroporphyrin IRGD 
HmbsRatporphyrin-containing compound metabolic process  IDA PorphobilinogenRGD 
HmbsRatresponse to xenobiotic stimulus  IDA SulfonamideRGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HMBSHumanheme biosynthetic pathway   ISORGD:2801 RGD 
HmbsRatheme biosynthetic pathway   IMP  RGD 
HmbsMouseheme biosynthetic pathway   ISORGD:2801 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Hmbs  (hydroxymethylbilane synthase)

Genes (Mus musculus)
Hmbs  (hydroxymethylbilane synthase)

Genes (Homo sapiens)
HMBS  (hydroxymethylbilane synthase)


Additional Information